高血压脑出血患者血清TNF-α、VEGF、ET-1水平的变化及意义

CHANGES AND SIGNIFICANCE OF SERUM TNF-Α, VEGF AND ET-1 LEVEL IN PATIENTS WITH HYPERTENSIVE CEREBRAL HEMORRHAGE

目的:探讨高血压脑出血(hypertensive cerebral hemorrhage,HICH)患者血清肿瘤坏死因子-α(TNF-α)、血管内皮生长因子(VEGF)和内皮素-1(ET-1)水平的变化及临床意义。方法:采用ELISA法检测HICH患者及健康体检者血清TNF-α、VEGF和ET-1的水平,并分析不同GCS评分HICH患者血清TNF-α、VEGF和ET-1水平的变化情况。结果:HICH患者血清TNF-α、VEGF和ET-1水平均明显高于健康体检者(P<0.05)。并且,随着HICH患者GCS评分的降低,血清TNF-α、VEGF和ET-1水平逐渐升高(P<0.05)。结论:检测HICH患者血清TNF-α、VEGF和ET-1水平,对于HICH患者病情和预后判断有重要意义。

Objective： To investigate the changes and clinical significance of serum tumor necrosis factor-α（TNF-α）, vascular endothelial growth factor（VEGF） and endothelin-1（ET-1） level in patients with hypertensive cerebral hemorrhage（HICH）. Methods： ELISA was used to detect the serum TNF-α, VEGF and ET-1 level of HICH patients and healthy controls; And the serum TNF-α, VEGF and ET-1 level of HICH patients with different GCS scores were analyzed. Results： The serum TNF-α, VEGF and ET-1 level of HICH patients were significantly higher than healthy controls（P〈0.05）. Along with decreasing of GCS score in HICH patients, the serum TNF-α, VEGF and ET-1 level gradually increased（P〈0.05）. Conclusions： Detection of serum TNF-α, VEGF and ET-1 level play important role in diagnosis and prognosis of HICH patients.