肝硬化失代偿期患者并发真菌感染危险因素分析

Anlysis of risk factors of decompensated cirrhosis patients with fungal infections

目的探讨肝硬化失代偿期患者并发真菌感染的危险因素。方法选择2013年6月至2016年6月安徽医科大学第一附属医院收治的肝硬化失代偿期患者197例。根据是否合并真菌感染,分为真菌感染组(17例)和未真菌感染组(180例)。收集患者年龄、性别、住院天数、凝血酶原时间、肝功能分级、血清白蛋白水平、抗菌药物使用时间、有无糖尿病、有无肝性脑病、有无侵入性操作史、有无消化道出血、有无自发性腹膜炎、有无饮酒史等临床资料,分析合并真菌感染的危险因素。结果 197例患者的真菌感染发生率为8.63%,住院天数、肝功能分级、血清白蛋白水平、抗菌药物使用时间是肝硬化失代偿期患者发生真菌感染的独立危险因素。结论肝硬化失代偿期患者并发真菌感染的危险因素复杂,感染不易及时识别,应加强临床防治。

Objective To investigate the related clinical factors of fungal infection in patients with decompensated cirrhosis. Methods A total of 197 patients with decompensated liver cirrhosis were enrolled from June 2013 to June 2016. According to whether they were with or without fungal infections,they were divided into two groups： the fungal infection group（ 17 cases） and the non-fungal infection group（ 180 cases）. Age,gender,duration of hospitalization,prothromin time,liver function classification,serum albumin,antibiotic use time,with or without diabetes,with or without hepatic encephalopathy,with or without invasive operation history,with or without gastrointestinal bleeding,with or without spontaneous peritonitis,with or without the dringking of history were collected to analyze the risk factors of fungal infection with decompensated cirrhosis. Results The fungal infection rate was 8. 63%. The length of hospital stay,liver function Child grade C,serumalbumin,antibiotic use time were the independent risk factors of fungal infection in decompensated liver cirrhosis patients.Conclusion The risk factors of fungal infection in patients with decompensated cirrhosis are complicated. Fungal infection is difficult to identify in time,thus the clinical prevention and treatment should be strengthened.