结核感染T细胞斑点试验在淋巴结结核中的诊断意义

Diagnostic value of T-cell spot of tuberculosis in lymph node tuberculosis

目的探讨结核感染T细胞斑点试验(T-cell spot of tuberculosis,T-spot.TB)对于单纯淋巴结结核的诊断意义。方法选取2015年9月1日~2017年2月1日就诊于西安市胸科医院的单纯淋巴结肿大的患者(不合并有肺结核),分别采取T-spot.TB和结核菌素实验(tuberculin skin test,TST)进行检测;分析比较两种方法对于疾病诊断的意义(包括灵敏度、特异性等)。结果结核感染T细胞斑点试验的灵敏性和特异性明显高于结核菌素试验(X^2=13.72,P<0.05);同时,结核感染T细胞斑点试验的假阳性率和假阴性率明显低于结核菌素试验(P<0.05)。结论结核感染T细胞斑点试验在诊断淋巴结结核中具有良好的敏感性和特异性,对于单纯淋巴结肿大的患者具有重要临床应用价值。

Objective To investigate the diagnostic value of T-cell spot of tuberculosis（T-spot. TB）in simple lymph node tuberculosis.Methods To select the patients with simple lymphadenopathy who were visited to Xi＇an chest hospital from September 1 st 2015 to February 1 st2017（without pulmonary tuberculosis）, and take the T-spot.TB and tuberculin skin test tuberculin experiment respectively（TST）respectively; and to analysis and compare the disease diagnosis significance of two methods（including sensitivity, specificity etc）. Results The sensitivity and specificity of T-spot.TB were higher than TST significantly（P〈0.05）; at the same time, the false positive rate and false negative rate of T-spot.TB were lower than TST significantly（P〈0.05）. Conclution T-spot. TB had higher sensitivity and specificity in the diagnosis of lymph node tuberculosis, and was importantly clinical value in patients with simple lymphadenopathy.