基础胰岛素联合西格列汀片对血糖控制及氧化应激及炎症反应的影响

Effects of basal insulin combined with Sitagliptin Phosphate Tablets on blood glucose control,oxidative stress and inflammatory response

目的:研究基础胰岛素联合西格列汀片对血糖控制及氧化应激及炎症反应的影响。方法:选择我院收治的二甲双胍单药治疗血糖控制不佳的2型糖尿病患者作为研究对象,随机分为两组,实验组接受二甲双胍+基础胰岛素+西格列汀治疗,对照组接受二甲双胍+格列美脲治疗。治疗前及治疗后3个月,测定糖化血红蛋白水平以及氧化应激指标、炎症反应指标的含量。结果:与治疗前比较,两组患者治疗后3个月时的糖化血红蛋白水平、血清中AGEs、MDA、CRP、TNF-α、IL-6、IL-8、VCAM-1的含量以及外周血中Nrf2、HO-1、NOX2、NOX4的表达强度均显著降低,血清中SOD、CAT的含量均显著升高且实验组治疗后3个月时的糖化血红蛋白水平、血清中AGEs、MDA、CRP、TNF-α、IL-6、IL-8、VCAM-1的含量以及外周血中Nrf2、HO-1、NOX2、NOX4的表达强度均显著低于对照组,血清中SOD、CAT的含量均显著高于对照组。结论:基础胰岛素联合西格列汀片用于二甲双胍单药治疗血糖控制不佳的2型糖尿病患者能够改善血糖控制情况并减轻氧化应激及炎症反应。

Objective：To study the effects of basal insulin combined with Sitagliptin Phosphate Tablets on blood glucose control,oxidative stress and inflammatory response.Methods：Type 2 diabetic patients with poor blood glucose control after metformin monotherapy in our hospital between March 2015 and July 2017 were selected as the research subjects and divided into two groups by random number table method,the experimental group received metformin ＋ basal insulin ＋ sitagliptin treatment,and control group were treated with metformin＋ glimepiride.The levels of glycosylated hemoglobin as well as the contents of oxidative stress indexes and inflammatory response indexes were measured before treatment and 3 months after treatment.Results：Compared with those before treatment,glycosylated hemoglobin levels,serum AGEs,MDA,CRP,TNF-α,IL-6,IL-8 and VCAM-1 contents as well as peripheral blood Nrf2,HO-1,NOX2 and NOX4 expression intensity of both groups significantly decreased while serum SOD and CAT contents significantly increased 3 months after treatment,and glycosylated hemoglobin level,serum AGEs,MDA,CRP,TNF-α,IL-6,IL-8 and VCAM-1 contents as well as peripheral blood Nrf2,HO-1,NOX2 and NOX4 expression intensity of experimental group 3 months after treatment were significantly lower than those of control group whereas serum SOD and CAT contents were significantly higher than those of control group.Conclusion：Basal insulin combined with Sitagliptin Phosphate Tablets can improve the blood glucose control condition and reduce the oxidative stress and inflammatory response in type 2 diabetic patients with poor blood glucose control after metformin monotherapy.