老年乳腺癌患者细胞因子及血清肿瘤标志物变化研究

The value of serum tumor markers and cytokines detection in elderly patients with breast cancer

目的:研究血清肿瘤标志物CA125、CA153、CEA、β-hCG、CA199、CYFRA21-1、TPS及细胞因子IL-6、TNF-α、IL-8、GDF-3水平在乳腺癌诊断中的价值,为临床诊治提供参考。方法:选取我院于2015年11月~2017年11月期间收治的乳腺癌患者293例作为观察组,另选取同期收治的良性乳腺疾病患者125例,来院参加体检的健康体检者125例作为对照组。采用多肿瘤标志物蛋白质芯片检测系统及酶联免疫法对比检测三组受试者血清肿瘤标志物及细胞因子变化。结果:不同分期的乳腺癌各组的血清肿瘤标志物和细胞因子水平均高于对照组及良性乳腺疾病组,差异均有统计学意义(P<0.05);不同分期的乳腺癌各组间对比,随着分期的升高,其血清肿瘤标志物均升高,以Ⅳ期乳腺癌为最高,差异有统计学意义(P<0.05);良性乳腺疾病组与对照组对比,各指标差异无统计学意义(P<0.05);结论:血清肿瘤标志物CA125、CA153、CEA、β-hCG、CA199、CYFRA21-1、TPS及细胞因子IL-6、TNF-α、IL-8、GDF-3水平在乳腺癌中表达较高,且随时分期升高而升高,值得临床重视。

Objective： To study the value of serum tumor markers CA125, CA153, CEA, -hCG, CA199, CYFRA21-1, beta and TPS cytokines IL-6, TNF- alpha, IL-8 and GDF-3 levels in the diagnosis of breast cancer, and provide reference for clinical diagnosis and treatment. Methods： The 293 cases of breast cancer patients in our hospital from November 2015 to November 2017 were selected as the observation group. At the same time, 125 patients with benign breast disease were selected as benign breast disease group, and 125 cases of healthy persons who had received physical examination were selected as control group. Serum tumor markers and cytokine changes were detected by using multiple tumor markers protein chip detection system and enzyme-linked immunosorbent assay （ELISA） in three groups. Results： The levels of serum tumor markers and cytokines in different stages of breast cancer groups were higher than those in control group and benign breast disease group; the differences were statistically significant （ P 〈0.05）. Breast cancer staging between different groups and with the stage increasing, serum tumor markers were all elevated, and in stage IV, breast cancer reached the highest; the difference was statistically significant （ P 〈0.05）. Compared with the control group, there was no significant difference in each index in benign breast disease group （ P 〈0.05）. Conclusion： The serum tumor markers CA125, CA153, CEA, -hCG, CA199, CYFRA21-1, beta and TPS cytokines IL-6, TNF- alpha, IL-8, GDF-3 are higher in the expression level of breast cancer, and they rise with the stage increasing. Therefore, it is worthy of clinical attention.