头孢曲松钠联合炎琥宁注射液治疗小儿急性肺炎有效性与安全性的Meta分析

Efficacy and safety of Ceftriaxone Sodium and Yan Huning Injection in the treatment of pediatric acute pneumonia:a meta-analysis

目的系统评价头孢曲松钠联合炎琥宁注射液治疗小儿急性肺炎的有效性和安全性。方法由2位研究人员独立用计算机检索PubMed、EMbase、The Cochrane Library(2018年第1期)、VIP、CBM、CNKI和WanFang Data,搜集有关头孢曲松钠联合炎琥宁注射液治疗小儿急性肺炎的随机对照试验(RCT),试验组为头孢曲松钠联合炎琥宁注射液,对照组为单用头孢曲松钠治疗,检索自建库到2018年1月;以治疗总有效率、临床症状缓解时间以及不良反应为观察指标进行资料提取和质量评价后,采用RevMan 5.3软件进行Meta分析。结果共纳入14个RCT,共1937例患者,其中试验组994例,对照组943例。Meta分析结果显示:头孢曲松钠联合炎琥宁注射液治疗小儿急性肺炎的总有效率[RR=1.21,95%CI(1.17,1.26),P<0.00001]、退热时间[MD=-1.29,95%CI(-1.43,-1.15),P<0.00001]、止咳时间[MD=-2.70,95%CI(-3.01,-2.39),P<0.00001]、啰音消失时间[MD=-2.14,95%CI(-2.46,-1.81),P<0.00001]、X线恢复时间[MD=-2.54,95%CI(-2.62,-2.47),P<0.00001]、不良反应发生率[RR=0.23,95%CI(0.11,0.46),P<0.0001]均优于单用头孢曲松钠,其差异均有统计学意义。结论头孢曲松钠联合炎琥宁注射液治疗小儿急性肺炎的疗效优于单用头孢曲松钠,且安全性良好。

Objective To systematically evaluate the efficacy and safety of Ceftriaxone Sodium and Yan Huning Injection in the treatment of children with acute pneumonia. Methods Two researchers independently searched databases including PubMed, EMbase, the Cochrane Library（Issue 1, 2018）, VIP, CBM, CNKI, and Wan Fang Data by computer and randomized controlled trials（RCTs） on the treatment of acute pneumonia in children with Ceftriaxone Sodium and Yan Huanning Injection from database creating to January 2018 were collected, the experimental group was Ceftriaxone Sodium combined with Yan Huning Injection and the control group was Ceftriaxone Sodium alone. After taking the total effective rate, clinical symptom relief time and adverse reaction as the observation index for data extraction and quality evaluation, Meta-analysis was performed by using RevMan 5.3 software. Results A total of 14 RCTs involving 1937 patients were included. There were 994 cases in the experimental group and 943 cases in the control group. The results of Meta-analysis showed that Ceftriaxone Sodium and Yan Huning Injection in the treatment of children with acute pneumonia in the total effective rate [RR = 1.21, 95%CI（1.17,1.26）, P 0.00001], cooling time [MD =-1.29, 95%CI（-1.43,-1.15）, P 0.00001], cough-disappear time [MD =-2.70, 95%CI（-3.01,-2.39）, P 0.00001], rales disappear time [MD =-2.14, 95% CI（-2.46,-1.81）, P 0.00001], X-ray recovery time [MD =-2.54,95% CI（-2.62,-2.47）,P 0.00001], the incidence of adverse reactions [RR = 0.23,95%CI（0.11,0.46）,P 0.0001] were better than single Ceftriaxone Sodium with statistical significance. Conclusion The efficacy of Ceftriaxone Sodium and Yan Huning Injection in the treatment of acute pneumonia in children is superior to that of single Ceftriaxone Sodium and has a good safe.