重症患者疾病严重程度与维生素D水平的相关性探究

Correlation between Severity of Disease and Vitamin D Level in Critically Ill Patients

目的探讨重症患者疾病严重程度与维生素D水平的相关性。方法方便选取2015年12月—2016年12月该院收治的50例重症患者分成观察1组(n=33)与观察2组(n=17),进行一般指标对比,并与同期在该院门诊进行体检的50名健康人士的25-羟维生素D水平进行对比。结果两组患者的性别占比、血小板计数、CRP水平、血清钙水平及血清磷水平差异无统计学意义(P>0.05),而合并器官功能障碍占比、病死率、APACHEⅡ平均评分、25-羟维生素D水平、白细胞计数、乳酸均差异有统计学意义(P<0.05);重症患者的25-羟维生素D水平明显低于健康人士;APACHEⅡ评分与25-羟维生素D水平呈负相关。结论重症患者严重缺乏维生素D,疾病严重程度越重,维生素D水平越低。

Objective This paper tries to investigate the correlation between disease severity and vitamin D levels in critically ill patients. Methods 50 critically ill patients admitted to this hospital from December 2015 to December 2016 were divided conveniently into observation group 1（n=33） and observation group 2（n=17）. The general index of the 25-hydroxy vitamin D levels of 50 healthy people on physical examination of the same period in this hospital was compared. Results There was no significant difference in gender share, platelet count, CRP level, serum calcium level, and serum phosphorus level in the two groups. There was a significant difference in the ratio of combined organ dysfunction, mortality, APACHE II average score, 25-hydroxy vitamin D level, white blood cell countlactic acid and lactic acid; the 25-hydroxyvitamin D levels in critically ill patients were significantly lower than those in healthy individuals; the APACHE II score was negatively correlated with 25-hydroxyvitamin D levels. Conclusion Critically ill patients are severely deficient in vitamin D. The more severe the disease, the lower the vitamin D level.