精神分裂症孕妇妊娠期用药安全分析

Analysis of Drug Safety During Pregnancy in Schizophrenia

目的对精神分裂症孕妇妊娠期用药安全进行分析研究。方法方便选取2016年1—12月湖北省襄阳市安定医院精神科和幼保健院妇产科共同收治的35例精神病孕妇作为研究对象,同时选取35例正常妊娠期妇女作为对照组,观察组孕妇给以抗精神药物,对照组孕妇未采取任何治疗,对比整个妊娠期,以及生产、新生儿的具体情况。结果观察组孕妇经过服用抗精神药物之后,直接影响了腹中的胎儿,导致妊娠期孕妇出现流产、死胎、宫内发育异常的几率分别是14.29%、8.57%和20.0%,远远高于对照组,差异有统计学意义(P<0.05);观察组精神分裂症孕妇所诞生的婴儿畸形发生率22.86%,对照组为5.71%,数据对比,差异有统计学意义(P<0.05);在大剂量服用药物患者新生儿缺陷发生率明显高于低剂量服药组,差异有统计学意义(P<0.05)。结论精神分裂症孕妇在妊娠期间,用药会大大降低婴儿的健康,必须要加强安全用药管理,以有效降低对胎儿健康的危害,具有较高的临床推广价值。

Objective This paper tries to analyze the drug safety of pregnant women with schizophrenia. Methods 35 cases of mentally ill pregnant women from January to December 2016 were selected conveniently from the Department of Psychiatry at Anding Hospital, and the Department of Obstetrics and Gynecology at the Children＇s Hospital. At the same time, 35 cases of normal pregnant women were selected as the control group. The observation group was given antipsychotic drugs and the control group did not take any treatment and compared the entire period of pregnancy, as well as the specific conditions of production and newborns. Results The pregnant women in the observation group directly affected the fetuses in the abdomen after taking antipsychotic drugs, resulting in 14.29%, 8.57%, and 20.0% chance of abortions, stillbirths, and intrauterine abnormalities in pregnant women during pregnancy, which was much higher than that of the control group. The difference was statistically significant（P〈0.05）. The incidence of infant malformations born in pregnant women with schizophrenia was 22.86% in the observation group and 5.71% in the control group. The data were statistically significant（P〈0.05）; The incidence of neonatal deficiencies in patients taking doses of drugs was significantly higher than that in low dose groups, with a statistically significant difference（P〈0.05）. Conclusion During the pregnancy, the schizophrenia pregnant women with medication will greatly influence the baby＇s health, the management of safe medication must be strengthed,in order to effectively reduce the harm to the health of the fetus, which has a high value of clinical promotion.