益气化痰消瘿法对桥本甲状腺炎患者血清甲状腺球蛋白抗体的影响研究

Study on the Effect of Yiqi Huayu Decoction Method on Serum Thyroglobulin Antibody in Patients with Hashimoto's Thyroiditis

目的探讨益气化痰消瘿法对桥本甲状腺炎患者血清甲状腺球蛋白抗体的影响。方法方便选取该院2015年1月—2017年1月间收治的64例桥本甲状腺炎作为此次研究对象,按照随机数字表法分为对照组与实验组各32例,两组均给予西药他巴唑维持甲状腺正常功能,实验组则另外加用益气化痰消瘿中药汤剂进行治疗,对比两组临床疗效、治疗前后甲状腺功能、血清甲状腺球蛋白抗体变化以及安全性评价。结果实验组患者治疗总有效率(96.88%)明显高于对照组,差异有统计学意义(χ2=9.200,P<0.05);经治疗后实验组患者TGAb、TPOAb以及FT3、FT4、TSH分别为(323.90±31.16)U/m L、(1 221.07±30.60)U/m L、(3.64±0.25)pg/m L、(1.11±0.11)ng/d L、(1.30±0.41)μIU/m L,与对照组患者相较,实验组患者TGAb、TPOAb较同期对照组有明显好转,差异有统计学意义(t=8.095、2.783,P<0.05);且用药期间不良反应发生率(3.13%)明显低于对照组,差异有统计学意义(χ2=6.093,P<0.05)。结论采用中药益气化痰消瘿法治疗桥本甲状腺炎患者疗效显著,有助于降低甲状腺自身免疫性抗体指标,减轻甲状腺的自身免疫反应,是目前较为安全、疗效可观的治疗方案,值得临床推广应用。

Objective This paper tries to explore the effect of Yiqi Huayu Decoction on serum thyroglobulin antibody in patients with Hashimoto＇s thyroiditis. Methods 64 cases of Hashimoto＇s thyroiditis treated in this hospital from January2015 to January 2017 were convenient selected as the subject of this study. According to the random number table method,32 cases were divided into the control group and the experimental group, and both groups were given Western medicine.The azole maintains normal thyroid function. In the experimental group, Yiqi Huayu Xiaoyu Decoction was added for treatment. Clinical efficacy, thyroid function, changes in serum thyroglobulin antibodies, and safety evaluation before and after treatment of the two groups were compared. Results The total effective rate of treatment in the experimental group（96.88%）was significantly higher than that of the control group, and the difference was statistically significant（χ^2=9.200, P〈0.05）. After treatment, the TGAb, TPOAb, and FT3, FT4, and TSH in the experimental group were（323.90±31.16）U/m L,（1 221.07±30.60）U/m L,（3.64±0.25）pg/m L,（1.11±0.11）ng/d L,（1.30±0.41）u IU/m L. Compared with the control group, the TGAb and TPOAb of the experimental group were significantly better than the control group at the same time. The comparison was significant（t=8.095, 2.783, P〈0.05）; and the incidence of adverse reactions during treatment（3.13%） was significantly lower than the control group, the difference was statistically significant（χ^2=6.093, P〈0.05）. Conclusion The use of traditional Chinese medicine for replenishing qi and eliminating phlegm to treat Hashimoto＇s thyroiditis is effective in reducing thyroid autoimmune antibody and reducing thyroid autoimmune reaction. It is currently a safe and effective therapeutic solution and worthy of clinical promotion and application.