6-氧-叔丁基二甲基硅基-2,4-二-氧-苯甲酰基-3-氧-对甲氧基苄基-α-D-甘露吡喃糖乙硫苷的合成

Synthesis of Ethyl-2,4-di-O-benzoyl-3-O-p-methoxybenzyl-6-O-tert-butyldimethyl Silyl-1-thio-α-D-mannopyranoside

以D-甘露糖为原料,通过乙酰化、去乙酰化、苯亚甲基化、硅基化等8步反应合成了6-氧-叔丁基二甲基硅基-2,4-二-氧-苯甲酰基-3-氧-对甲氧基苄基-α-D-甘露吡喃糖乙硫苷,总收率21.7%,其结构经~1H NMR,^(13)C NMR,IR和LC-MS(ESI)确证。

Ethyl-2,4-di-O-benzoyl-3-O-p-methoxybenzyl-6-O-tert-butyldimethyl silyl-1-thio-α-D-mannopyranoside was synthesized from D-Mannose by eight-step of acetylation,deactylation,benzylidenation,silylation,etc,with an overall yield of 21. 7%. The structure was confirmed by^1H NMR,^13C NMR,IR and LC-MS（ESI）.