药物辅助性犯罪案件中新型苯二氮幕卓类策划药2-氯地西泮的鉴定

Identification of New Designer Benzodiazepine Diclazepam in Drug Facilitated Sexual Assault

目的利用高分辨质谱等技术鉴定药物辅助性犯罪案件中涉及的不在常规检测范围的、完全未知的新型策划药,解决实际案例中的证据问题。方法实际案例中缴获的乳白色液体经提取后使用LC-QE、~1H-NMR和GC-MS等方法进行分析。通过LC-QE获得未知化合物的精确质量数和同位素离子峰簇特征,结合~1H-NMR的质子数确定元素组成为C_(16)H_(12)Cl_2N_2O。通过GC-MS分离、分析同分异构体2-氯地西泮和4-氯地西泮。结果乳白色液体中检出新型苯二氮菒卓类策划药2-氯地西泮,为案件的侦查和定性提供直接证据。结论 LC-QE、~1H-NMR和GC-MS等多种方法联合应用可进行未知、新型精神活性物质鉴定。

Objective To identify the new designer drugs which are totally unknown and not in the routine testing list by the technologies such as high-resolution mass spectrometry in drug facilitated sexual assault,in order to solve the problem in actual cases.Methods The milky fluid from an actual case was extracted and analyzed using LC-QE,~1H-NMR and GC-MS,respectively.The accurate masses and cluster ions isotope patterns of unknown compound were obtained by LC-QE.The molecular formula was confirmed as C_（16）H_（12）Cl_2N_2O based on the protons number of^1H-NMR.The isomers diclazepam and 4-chlorodiazepam were separated and detected with GC-MS.Results The new designer benzodiazepine as diclazepam in the milky fluid was identified.The results provided direct evidence for the investigation and qualitative analysis of such cases.Conclusion The combined application of various methods,including LC-QE,~1H-NMR and GC-MS,can be used to detect unknown new psychoactive substances.