抑郁症患者客观睡眠与临床特征的相关性

Relationship with the objective sleep and the depressive symptom level of depression patients

目的分析抑郁症患者的客观睡眠,探讨患者睡眠状况与抑郁症状的关系。方法 34例抑郁症患者为抑郁症组,21例健康者为健康对照组,两组均进行多导睡眠监测(polysomnography,PSG)。采用汉密尔顿抑郁量表(HAMD-24)对抑郁症组临床症状进行评估。结果 (1)与健康对照组相比,抑郁症组总睡眠时间(TST)减少[(463.90±45.76)min比(426.57±83.85)min(P<0.05)],睡眠潜伏期(SL)延长[(20.47±5.94)min比(46.49±55.42)min(P<0.01)]、快眼动睡眠(REM)减少[(81.91±29.05)min比(55.66±39.76)min(P<0.05)]及快眼动睡眠比例(REM%)[(17.28±6.00)%比(12.91±8.65)%(P<0.05)]降低。(2)Pearson相关分析显示,抑郁症组的HAMD-24得分与N3(r=-0.353,P<0.05)存在负相关。结论抑郁症患者的睡眠状况较正常存在明显变化;抑郁症患者抑郁程度越重,深睡眠时间就越少,睡眠紊乱状况也越重。

Objective To analyze the objective sleep characteristics of depression patients,and its relationship with the depressive symptom level. Methods 34 cases of depression patients and 21 normal controls were monitored with polysomnography（PSG）. Hamilton depression scale（HAMD-24） was used to evaluate depressive level of the patients group. Results（1） Compared with normal control group,depression patients showed significant reduced time in total sleep time（TST） [（463. 90 ± 45. 76） min vs.（426. 57 ±83. 85） min（P〈0. 05） ],rapid eye movement sleep（REM） [（81. 91 ± 29. 05） min vs.（55. 66 ± 39. 76） min（P〈0. 05） ],low percentage of REM [（17. 28 ± 6. 00） % vs.（12. 91 ± 8. 65） %,（P〈0. 05） ]. However,prolonged time in sleep latency（SL）[（20. 47 ± 5. 94） min vs.（46. 49 ± 55. 42） min（P 〈0. 01） ].（2） Pearson correlation analysis showed there was a negative correlation between N3 and the score of HAMD-24（r =-0. 353,P〈0. 05）. Conclusion Compared with normal controls,depressive patients showed more problems during night sleep. The severe depression patients is,the little time in deep sleep taken,also with more sleep disorders during the whole night.