钆塞酸二钠在肝细胞癌诊断中的价值

Value of Gd-EOB-DPTA in the diagnosis of hepatocellular carcinoma

钆塞酸二钠(Gd-EOB-DTPA)是一种具有双对比成像功能的肝胆特异性对比剂,既可以通过动态增强反映病灶血供信息,还可以通过肝胆特异期成像反映肝细胞膜分子受体表达变化。Gd-EOB-DTPA能够多维度反映肝硬化结节多步癌变信息,提高乏血供肝细胞癌(HCC)及小肝癌的检出率,显示高危肝硬化结节,已被多项国内外临床实践指南用于HCC的无创性诊断。就Gd-EOB-DTPA在HCC中的诊断价值作一论述。

Gd-EOB-DPTA is a hepatocyte-specific contrast agent with the function of double-contrast imaging. It can reflect the blood supply of lesions via dynamic enhancement imaging and show the change in the expression of molecular receptors on hepatocyte membrane via hepatobiliary phase imaging. Gd-EOB-DPTA can reflect the multistep process of hepatocarcinogenesis from multiple dimensions,improve detection of hypovascular hepatocellular carcinoma（ HCC） and small HCC,display cirrhotic nodules with high-risk malignant transformation,and therefore,it has been recommended as a noninvasive tool for HCC diagnosis in China and international HCC clinical practice guidelines. This article reviews the recent advances of Gd-EOB-DTPA in the diagnosis of HCC.