摘要
目前肝细胞癌(HCC)的主要治疗手段包括手术、化疗和放疗等。随着分子生物学技术的不断发展,分子靶向治疗迅速崛起。针对HCC发生发展相关的信号通路中某些特定位点设计靶向药物,成为HCC治疗研究的新热点。就近年来HCC的相关信号通路和对应的靶向治疗药物进行简要阐述。
At present,the main treatment methods for hepatocellular carcinoma( HCC) include surgery,chemotherapy,and radiotherapy.With the development of molecular biological techniques,the field of molecular targeted therapy is developing rapidly. The design of targeted drugs based on some specific sites in the signaling pathways involved in the development and progression of HCC has become a new research hotspot. This article elaborates on the pathways involved in the development and progression of HCC and targeted drugs for treatment.
作者
陈万勇
任宁
CHEN Wanyong;REN Ning(Department of Liver Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2018年第7期1387-1394,共8页
Journal of Clinical Hepatology
关键词
癌
肝细胞
分子生物学
药物释放系统
信号传导
carcinoma
hepatocellular
molecular biology
drug delivery systems
signal transduction