基于单中心的国产卡介苗治疗非肌层浸润性膀胱癌临床应用分析

Analysis of clinical application and adverse reactions of domestic BCG vaccine in the treatment of non-muscle invasive bladder cancer based on single Clinical center

目的:探讨国产卡介苗(BCG)治疗非肌层浸润性膀胱癌(NMIBC)的不良反应及其处理。方法:选择36例采用新型国产BCG膀胱灌注治疗的NMIBC患者,分析其不良反应及相应的处理措施。结果:30例(83.3%)患者灌注后出现明显的尿频、尿急及尿痛等膀胱刺激症状;12例(33.3%)患者灌注后出现发热等流感样症状;11例(30.6%)患者灌注后出现血尿。患者未出现附睾睾丸炎、结核性败血症或肝炎,未出现药物过敏等全身反应。较轻微的不良反应自行消失;较严重的不良反应给予对症处理后症状均缓解。结论:国产卡介苗治疗NMIBC安全、有效,不良反应较少,值得进一步推广。

Objective：To explore the adverse reactions and corresponding treatments of domestic BCG in treating nonmuscle invasive bladder cancer.Methods：The data of adverse reactions and corresponding treatments of novel domestic BCG in treating non-muscle invasive bladder cancer（NMIBC）in 36 cases were retrospectively analyzed.Results： After bladder perfusion therapy,30 patients（83.3%）showed obvious bladder irritation symptoms such as frequent micturition,urgency of micturition,and odynuria;12 patients（33.3%）showed flu-like symptoms such as fever;hematuria were found in 11 patients（30.6%）.No patient had epididymis,tuberculous sepsis,or hepatitis;and no patient had systemic reactions such as drug allergy.Mild adverse reactions disappeared without treatment;serious adverse reactions were relieved after symptomatic treatment.Conclusions：The domestic BCG is safe and effective in the treatment of NMIBC,with less adverse reactions,which is worthy of further promotion.