粪菌移植治疗儿童复发性艰难梭菌感染6例临床疗效评价

Clinical efficacy of fecal microbiota transplantation for pediatric recurrent Clostridium difficile infection

目的:探讨粪菌移植治疗儿童复发性艰难梭菌感染(recurrent Clostridium difficile infection,RCDI)的临床疗效。方法:收集上海市儿童医院消化科2014—2016年间收治的6例RCDI患儿接受粪菌移植治疗的临床资料。通过分析患儿的性别、年龄、临床表现、腹部CT检查图像以及粪菌移植治疗的次数、剂量和给予途径来评估粪菌移植治疗儿童RCDI的临床疗效。结果:共入组6例患儿。2例患儿经单次粪菌移植治疗达到临床治愈,4例患儿经多次粪菌移植治疗达到临床治愈。6例患儿在粪菌移植治疗期间及之后的随访中均未出现严重的不良反应。结论:粪菌移植治疗可用于儿童RCDI,其治疗有效且安全、耐受性好。

Objective： To evaluate the clinical efficacy of fecal microbiota transplantation（FMT） on children with recurrent Clostridium difficile infection（RCDI）. Methods： Clinical data from 6 patients diagnosed as RCDI and treated with FMT at Shanghai Children＇s Hospital from 2014 through 2016 were analyzed. The clinical efficacy of FMT for RCDI was evaluated by analysis of the gender, age, clinical manifestation, abdominal CT examination images of children and the frequency, dose, and route of FMT. Results： Among the 6 patients, 2 children received a single FMT treatment and achieved clinical cure and 4 children were treated with multiple FMT and achieved clinical cure. No severe adverse reaction occurred during FMT and followup. Conclusion： FMT can be used to treat children with RCDI and its treatment is effective, safe and well tolerant.