CD133、基质金属蛋白酶-2在老年结肠癌组织中的表达及其与预后的关系

Expressions of CD133 and Matrix Metalloproteinases-2 in the Elderly Patients with Colon Cancer

目的探讨CD133和基质金属蛋白酶-2(MMP-2)在老年结肠癌组织中的表达及其与预后的关系。方法用免疫组化法检测67例老年结肠癌组织中CD133和MMP-2的表达情况,并分析CD133和MMP-2与老年结肠癌患者临床病理特征及预后的关系。结果 CD133主要表达于细胞膜,MMP-2主要表达于细胞质或细胞膜。CD133的表达与淋巴结转移及UICC分期密切相关(P=0.004、0.007);MMP-2的表达与肿瘤侵犯层次、淋巴结转移及UICC分期密切相关(P=0.032、0.004、0.030)。老年结肠癌组织中CD133的表达和MMP-2的表达无明显相关性(r=0.042,P=0.733)。CD133和MMP-2阳性表达的患者5 a生存率明显低于阴性表达者(P=0.030、0.046)。结论 CD133和MMP-2在老年结肠癌的发展、侵袭过程中起到了促进作用,两者可作为评估老年结肠癌患者预后的参考指标。

Objective To investigate the expressions of CD133 and matrix metalloproteinases-2（MMP-2） protein in the elderly patients with colon cancer and its association with the prognosis. Methods The expressions of CD133 and MMP-2 protein in the 67 elderly patients with colon cancer were detected by immunohistocheimcal staining. The relationship of CD133 and MMP-2 protein with the clinicopathological characters were analyzed. Results CD133 were expressed on the cell membranes and MMP-2 were expressed on the cytoplasm or cell membranes. CD133 were associated with lymph nodes metastasis and UICC stage（ P = 0. 004,0. 007）. MMP-2 were associated with lymph nodes metastasis,UICC stage and tumor invasion level（ P = 0. 032,0. 004,0. 030）. There was no correlation between the expressions of CD133 and MMP-2 protein（ r = 0. 042,P = 0. 733）. The 5-year survival rates of patients with positive expression of CD133 or MMP-2 were shorter than those of negative patients（ P = 0. 030,0. 046）. Conclusion The expressions of CD133 and MMP-2 are related to progression and prognosis of elderly patients with colon cancer. The two indexes provides the important evidence for predicting the progression and prognosis of elderly patients with colon cancer.