小剂量多巴胺结合多巴酚丁胺辅助治疗小儿重症肺炎的临床效果及安全性

Clinical efficacy and safety of low-dose dopamine combined with dobutamine in the treatment of pediatric severe pneumonia

目的研究对小儿重症肺炎患者辅助使用小剂量多巴胺结合多巴酚丁胺的临床效果及安全性。方法选取我院收治的重症小儿肺炎患儿116例为研究对象,按照治疗方案的不同分对照组(58例)和研究组(58例),对照组常规治疗,研究组联合使用小剂量多巴胺以及多巴酚丁胺。比较两组患儿肺炎相关症状改善恢复时间,治疗前、后患儿血清炎症因子水平及不良反应发生情况。结果治疗后,两组血清炎症因子明显改善,且研究组优于对照组(P<0.05);研究组的肺炎相关症状的改善恢复时间明显短于对照组(P<0.05);两组患儿不良反应总发生率比较,差异无统计学意义(P>0.05)。结论对小儿重症肺炎患者辅助使用小剂量多巴胺结合多巴酚丁胺治疗效果确切,能够有效改善患儿的症状,临床应用安全性很高。

Objective To study the clinical efficacy and safety of low-dose dopamine combined with dobutamine in the treatment of pediatric severe pneumonia. Methods One hundred and sixteen children with severe pneumonia were selected and randomly divided into control group（n=58） and study group（n=58）. The children in the control group were given conventional treatment, the study group added low-dose dopamine and dobutamine. The recovery time of pneumonia symptoms, the serum inflammatory before and after treatment, the incidence of adverse reactions in the two groups were compared. Results After treatment, the serum inflammatory factors in both groups significantly improved, and those in the study group were better than the control group（P 〈0.05）. The improvement and recover times of the symptoms related to pneumonia in the study group were shorter than those in the control group（P〈0.05）. There were no significant difference in the total incidences of adverse reactions between the two groups（P〉0.05）. Conclusion The treatment of low-dose dopamine combined with dobutamine in pediatric severe pneumonia has satisfactory effect and can effectively improve the symptoms of pediatric severe pneumonia. The safety of clinical application is very high.