急性心肌梗死患者血清BNP、Hcy、hs-CRP与甲状腺激素变化的检验分析

Analysis of Changes of Serum BNP,Hcy,hs-CRP and Thyroid Hormone in Patients with Acute Myocardial Infarction

目的探讨急性心肌梗死患者血清BNP、Hcy、hs-CRP与甲状腺激素变化的检验分析。方法选取该院2015年1月—2016年12月收治的90例急性心肌梗死患者为该研究观察组,均经临床检查确诊。再将观察组患者根据急性ST抬高型心肌梗死(STEMI)和非急性ST抬高型心肌梗死(NSTEMI)分为两组,另选择同时期来该院体检健康者40名为该研究对照组,检测患者血清BNP、Hcy、hs-CRP与甲状腺激素变化。结果观察组患者、STEMI组患者、NSTEMI组患者T3显著低于对照组,差异有统计学意义(P<0.05);STEMI组患者T3显著低于NSTEMI组,差异有统计学意义(P<0.05)。观察组患者血清BNP、Hcy、hs-CRP水平显著高于对照组,差异有统计学意义(P<0.05)。STEMI组(n=55)、NSTEMI组(n=35)、下后壁组(n=30)、前侧壁组(n=60)、再发梗死组(n=5)、初次梗死组(n=85)的BNP水平分别为(580.6±18.4)、(477.8±23.4)、(519.8±23.7)、(518.7±11.5)、(797.9±34.6)、(500.7±22.6)pg/m L。STEMI组患者血清BNP水平显著高于NSTEMI组,差异有统计学意义(t=29.993 3,P<0.05);再发梗死组患者血清BNP水平显著高于初次梗死组,差异有统计学意义(t=27.742 0,P<0.05);下后壁组患者与前侧壁组患者血清BNP水平对比差异无统计学意义(t=0.297 3,P>0.05)。结论急性心肌梗死患者血清BNP、Hcy、hs-CRP水平可以反映其病情严重程度,甲状腺激素水平可以帮助评估缺血缺氧程度,对患者治疗和预后意义重大。

Objective This paper tries to investigate the changes of serum BNP, Hcy, hs-CRP and thyroid hormone in patients with acute myocardial infarction （AMI）. Methods A total of 90 patients with acute myocardial infarction who were admitted to this hospital from January 2015 to December 2016 were selected as the observation group. All patients were diagnosed by clinical examination. The patients in the observation group were divided into two groups according to acute STEMI and non-acute ST elevation myocardial infarction （NSTEMI）. Another 40 patients who were selected for physical examination in this hospital were selected as the control group. The serum levels of BNP, Hcy, hs-CRP and thyroid hormones were measured. Results T3 in the observation group, STEMI group, and NSTEMI group was signifi- cantly lower than that in the control group （P〈0.05）; T3 in the STEMI group was significantly lower than that in the NSTEMI group （P〈0.05）. The serum levels of BNP, Hcy, and hs-CRP in the observation group were significantly higher than those in the control group, and the difference was statistically significant （P〈0.05）. The BNP levels for STEMI group （n=55）, NSTEMI group （n=35）, inferior posterior wall group （n=30）, anterior wall group （n=60）, recun＇ent infarction group （n =5）, primry infarction group （n =85）were （580.6±18.4）, （477.8±23.4）, （519.8±23.7）, （518.7±11.5）, （797.9±34.6）pg/mL, and （500.7±22.6）pg/mL, respectively. Serum BNP levels were significantly higher in the STEMI group than in the NSTEMI group （t=29.993 3, P〈0.05）. Serum BNP levels were significantly higher in the recurrent infarction group than in the primry infarction group （t=27.742 0,P〈0.05）; There was no significant difference in serum BNP levels between patients in the inferior posterior wall group and the anterior wall group, which was not statistically significant（t=0.297 3, P〉0.05）. Conclusion Serum BNP, Hcy, and hs-CRP levels in patients with acute myocardial infarction can reflect the severity of the disease, and thyroid hormone levels can help assess the degree of ischemia and hypoxia, which is of great significance for the treatment and prognosis of patients.