血浆置换联合DPMAS与单纯血浆置换治疗重型肝炎不良反应对比分析

Comparative Analysis of Adverse Reactions of Plasma Exchange Combined with DPMAS and Simple Plasma Exchange for Severe Hepatitis

目的分析血浆置换联合DPMAS在治疗重型肝炎不良反应发生情况。方法选取于2010年1月—2017年12月因重型肝炎来该科诊治的60例患者,按入院时间顺序随机分为两组:PE+DPMAS组(观察组)30例,PE组30例(对照组),分析两组不良反应情况。结果观察组的输血不良反应发生率明显低于对照组(3.3%vs 13.3%),差异有统计学意义(χ~2=4.320,P<0.05);其余不良反应差异无统计学意义。结论血浆置换联合DPMAS治疗重型肝炎可以很好改善患者临床症状同时降低输血不良反应发生率,且不增加其他不良反应发生率,值得推广应用。

Objective This paper tries to analyze plasma exchange and DPMAS in the treatment of severe hepatitis ad- verse events. Methods From January 2010 to December 2017, 60 patients were treated with severe hepatitis. According to the order of admission, they were randomly divided into 2 groups： 30 patients in PE ＋DPMAS group （observation group） and 30 patients in PE group （control group）. The adverse reactions of the two groups were compared. Results The incidence of adverse reactions to transfusion in the observation group was significantly lower than that in the con- trol group （3.3% vs 13.3%）. The difference was statistically significant （X2=4.320, P〈0.05）; the other adverse reactions were not statistically significant. Conclusion Plasma exchange combined with DPMAS treatment of severe hepatitis can improve the clinical symptoms of patients and reduce the incidence of adverse reactions, and does not increase the in- cidence of other adverse reactions, it is worth promoting.