八段锦结合药物治疗对急性心肌梗死患者心脏康复的作用

Effects of Baduanjin combined medication on cardiac rehabilitation in patients with acute myocardial infarction

目的:探讨八段锦结合药物治疗对急性心肌梗死(AMI)患者心脏康复的作用。方法:选择我院收治的AMI患者106例作为研究对象,按照随机数字表法分为药物治疗组(常规治疗基础上加用通心络)和联合治疗组(在药物治疗组基础上联合八段锦运动),各53例。治疗4周,观察并比较两组临床疗效、左室舒张末期容积(LVEDV)、左室收缩末内径(LVESd)、左室射血分数(LVEF)、肿瘤坏死因子-α(TNF-α)、高敏C反应蛋白(hsCRP)、白介素-6(IL-6)、N末端B型利钠肽原(NT-proBNP)水平。结果:联合治疗组总有效率显著高于药物治疗组(92.45%比75.47%,P=0.017);与治疗前比较,治疗后两组LVEDV、LVEF水平显著提高,LVESd显著缩小,hsCRP、TNF-α、IL-6、NT-proBNP水平明显降低(P<0.05或<0.01),且与药物治疗组比较,联合治疗组治疗后LVEDV[(153.58±25.17)ml比(165.27±25.46)ml]、LVEF[(51.43±4.28)%比(55.37±4.26)%]水平显著提高,LVESd[(33.46±2.24)mm比(30.29±2.32)mm]显著缩小,hsCRP[(4.54±1.12)mg/L比(3.48±1.05)mg/L]、TNF-α[(117.85±15.46)ng/L比(96.59±14.23)ng/L]、IL-6[(14.38±3.34)pg/ml比(10.67±3.29)pg/ml]、NT-proBNP[(456.29±53.76)ng/L比(368.49±53.65)ng/L]水平明显降低(P<0.05或<0.01)。结论:八段锦结合通心络胶囊能够有效改善急性心肌梗死患者心功能,降低炎症因子水平,提高治疗效果。

Objective：To explore effects of Baduanjin combined medication on cardiac rehabilitation in patients with acute myocardial infarction（AMI）.Methods：A total of 106 AMI cases treated in our hospital were enrolled.According to random number table,they were randomly and equally divided into medication group（received Tongxinluo based on routine treatment）and combined treatment group（received Baduanjin exercise based on medication group）,both groups were treated for four weeks.Left ventricular end-diastolic volume（LVEDV）,left ventricular end-systolic dimension（LVESd）,left ventricular ejection fraction（LVEF）,levels of tumor necrosis factor（TNF）-α,high sensitive C reactive protein（hsCRP）,interleukin（IL）-6 and N terminal pro brain natriuretic peptide（NTproBNP）were observed and compared between two groups.Results：Total effective rate of combined treatment group was significantly higher than that of medication group（92.45% vs.75.47%,P=0.017）.Compared with before treatment,after treatment,there were significant rise in LVEDV and LVEF,and significant reductions in LVESd,levels of hsCRP,TNF-α,IL-6 and NT-proBNP in two groups（P〈0.05 or〈0.01）.Compared with medication group after treatment,there were significant rise in LVEDV [（153.58±25.17）ml vs.（165.27±25.46）ml],LVEF[（51.43±4.28）% vs.（55.37±4.26）%],and significant reductions in LVESd[（33.46±2.24）mm vs.（30.29±2.32）mm],levels of hsCRP [（4.54±1.12）mg/L vs.（3.48±1.05）mg/L],TNF-α[（117.85±15.46）ng/L vs.（96.59±14.23）ng/L],IL-6 [（14.38±3.34）pg/ml vs.（10.67±3.29）pg/ml],NT-proBNP [（456.29±53.76）ng/L vs.（368.49±53.65）ng/L]in combined treatment group,P〈0.05 or〈0.01.Conclusion：Baduanjin combined Tongxinluo capsule can effectively improve cardiac function,reduce levels of inflammatory factors and improve therapeutic effect in patients with acute myocardial infarction.