活血散精简方治疗膝关节骨关节炎的临床疗效研究

Clinical Effect of Simplified Huoxue Powders in the Treatment of Knee Osteoarthritis

目的探讨活血散精简方治疗膝关节骨关节炎(KOA)的临床疗效。方法选取2017年2—6月中国中医科学院广安门医院骨科门诊收治的KOA患者96例。根据患者用药意愿分为活血散原方组30例、温经通络方组19例、行气活血方组17例和活血散精简方组30例。4组分别给予活血散原方、温经通络方、行气活血方和活血散精简方外敷,均治疗14 d。比较4组患者膝关节疼痛视觉模拟评分法(VAS)评分、骨关节炎指数(WOMAC)评分、中医证候积分。结果治疗前4组膝关节疼痛VAS评分比较,差异无统计学意义(P>0.05);治疗后活血散精简方组膝关节疼痛VAS评分低于温经通络方组,差异有统计学意义(P<0.05);治疗后活血散原方组、行气活血方组、活血散精简方组患者膝关节疼痛VAS评分低于治疗前,差异有统计学意义(P<0.05)。治疗前4组WOMAC评分比较,差异无统计学意义(P>0.05);治疗后活血散原方组、活血散精简方组WOMAC评分低于行气活血方组,差异有统计学意义(P<0.05);治疗后4组WOMAC评分低于治疗前,差异有统计学意义(P<0.05)。治疗前4组中医证候积分比较,差异无统计学意义(P>0.05);治疗后活血散原方组、活血散精简方组中医证候积分低于温经通络方组,差异有统计学意义(P<0.05);治疗后活血散原方组、行气活血方组、活血散精简方组患者中医证候积分低于治疗前,差异有统计学意义(P<0.05)。结论活血散精简方可以有效地缓解KOA患者的膝关节疼痛的临床症状,改善KOA患者的病情。

ObjectiveTo discuss the clinical effect of the simplified huoxue powders on knee osteoarthritis（KOA）.MethodsWe enrolled 96 orthopedic outpatients with KOA from Guang＇anmen Hospital,China Academy of Chinese Medical Sciences from February to June 2017,and divided them into huoxue powders group（n=30）,wenjingtongluo group（n=19）,xingqihuoxue group（n=17）,simplified huoxue powders group（n=30）,receiving 14-day external treatment with huoxue powders prescription,wenjingtongluo prescription,xingqihuoxue prescription,simplified huoxue powders prescription,respectively.The Visual Analog Scale（VAS）score for subjective knee pain,WOMAC score and TCM syndrome score were compared between the groups at baseline and after treatment.ResultsVAS score,WOMAC score and TCM syndrome score at baseline did not differ significantly between the groups（P〉0.05）.After treatment,all of them except wenjingtongluo group decreased significantly in all groups（P〈0.05）.Moreover,intergroup comparisons showed that simplified huoxue powders group demonstrated much lower VAS score compared with wenjingtongluo group （P〈0.05）;xingqihuoxue group had substantially higher WOMAC score than both huoxue powders group and simplified huoxue powders group（P〈0.05）;xingqihuoxue group displayed much higher TCM syndrome score compared with huoxue powders group and simplified huoxue powders group （P〈0.05） .ConclusionSimplified huoxue powders prescription can relieve the knee pain and improve the conditions of KOA patients to some extent.