中药离子导入治疗糖尿病肾病的效果分析

Analysis of the curative effect of Chinese traditional medicine iontophoresis on treating diabetic nephropathy

目的观察分析中药离子导入治疗糖尿病肾病的临床效果。方法回顾性分析108例糖尿病肾病患者的病例资料,根据治疗方案不同分为对照组和观察组,其中对照组52例。对照组采用常规疗法,观察组在常规疗法基础上采用中药离子导入疗法。分析比较两组患者治疗前后尿清蛋白、尿素氮、血清肌酐、内生肌酐清除率指标、三酰甘油、胆固醇的变化。结果观察组经治疗后尿微量清蛋白(UAE)由(91±14)mg/24 h降至(42±7)mg/24 h,水平明显降低,差异有统计学意义(P<0.001);血清肌酐由(6.64±1.55)mmol/L降至(7.43±0.99)mmol/h,水平明显降低,差异有统计学意义(P=0.002);三酰甘油由(1.96±0.32)mmol/L降至(1.30±0.30)mmol/L,水平明显降低,差异有统计学意义(P<0.001);胆固醇由(6.34±1.35)mmol/L降至(4.43±0.30)mmol/L,水平明显降低,差异有统计学意义(P<0.001);对照组治疗前后尿微量清蛋白、尿素氮、血清肌酐、内生肌酐清除率水平、三酰甘油水平、胆固醇水平均差异无统计学意义(P>0.05)。结论中药离子导入疗法能够有效降低糖尿病肾病患者的尿清蛋白、血清肌酐水平,延缓慢性肾衰的进程,且可改善脂代谢。

Objective To observe and analyze the clinical effect of iontophoresis in the treatment of diabetic nephropathy. Methods The data of 108 patients with diabetic nephropathy were retrospectively analyzed. According to the randomized table method,the patients were divided into control group and observation group,52 cases in the control group. The control group used conventional therapy,and the observation group used traditional Chinese medicine iontophoresis on the basis of conventional therapy. The changes of urinary albumin,urea nitrogen,serum creatinine,creatinine clearance index,triglyceride,and cholesterol were analyzed before and after treatment in the two groups. Results After the treatment,the urinaty albumin excretion（ UAE） of the observation group decreased from（ 91 ± 14） mg/24 h to（ 42 ± 7） mg/24 h,and the level was significantly decreased（ P 〈 0. 001）. Serum creatinine was（ 6. 64 ± 1. 55）mmol/L,it decreased to（ 7. 43 ± 0. 99） mmol/h,the level was significantly decreased,and the difference was statistically significant（ P = 0. 002）. The triacylglycerol was reduced from（ 1. 96 ± 0. 32） mmol/L to（ 1. 30 ± 0. 30） mmol/L,and the level was significantly decreased. Statistical significance（ P 〈 0. 001）. Cholesterol decreased from（ 6. 34 ±1. 35） mmol/L to（ 4. 43 ± 0. 30） mmol/L,and the difference was statistically significant（ P 〈 0. 001）. Urine microalbumin urea,nitrogen serum creatinine,endogenous creatinine clearance,triglyceride levels and cholesterol levels were not statistically different before and after treatment in the control group（ P 〉 0. 05）. Conclusion Traditional Chinese medicine iontophoresis can effectively reduce UAE and serum creatinine levels in patients with diabetic nephropathy,delay the progression of chronic renal failure and improve lipid metabolism.