丁锷用中药熏洗方治疗膝骨关节炎之寒痹证的临床研究

Clinical research of professor Ding E in treating knee osteoarthritis by cold paralysis with traditional Chinese medicine fumigation

目的研究丁锷教授用中药熏洗方法治疗膝骨关节炎之寒痹证的临床疗效。方法将80例寒痹证膝骨关节炎患者按随机数字表法分为两组。治疗组予中药熏洗、硫酸氨基葡萄糖口服,对照组口服硫酸氨基葡萄糖。两组均治疗15 d后观察并比较临床疗效、视觉模拟评分(VAS评分)、中医证候积分、红细胞沉降率(ESR)、C反应蛋白(CRP)、超氧化物歧化酶(SOD)的变化情况。结果治疗后治疗组临床总有效率(97.5%)略高于对照组(90.0%),治疗组VAS评分[(3.37±0.92)分]低于对照组[(4.42±1.22)分]。两组患者治疗后中医证候总积分均优于治疗前(P<0.05),治疗组对于改善中医各症状较对照组更具优势。两组患者治疗后ESR、CRP、SOD水平均低于治疗前(P<0.05),两组比较:治疗前组间差异无统计学意义(P>0.05),治疗后ESR和SOD差异有统计学意义(P<0.05)。结论丁锷教授运用中药熏洗方治疗膝骨关节炎之寒痹证的患者具有较好的临床疗效。

Objective To study the clinic effect of Professor Ding E in treating knee osteoarthritis by cold paralysis with traditional Chinese medicine fumigation. Methods Eighty cases of patients with knee osteoarthritis were randomly divided into 2 groups. Treatment group was treated with traditional Chinese medicine fumigation and oral glucosamine sulfate,and the control group received oral glucosamine sulfate only. The 2 groups were treated for 15 days,the clinical efficacy,VAS score,TCM syndrome score,ESR,CRP and superoxide dismutase SOD of two groups were observed and compared. Results After treatment,the total effective rate of treatment group was slightly higher than that in the control group,and the score of VAS in the treatment group was lower than that in the control group. The total score of TCM syndromes in the 2 groups was better than that before treatment（ P 〈 0. 05）,and the treatment group was superior to the control group in the improvement of the symptoms of TCM. The ESR,CRP and SOD of the two groups were lower than those before treatment（ P 〈 0. 05）. The difference between the two groups was not statistically significant（ P 〉0. 05）,the difference of ESR and SOD between two groups showed significant differences after treatment（ P 〈 0. 05）.Conclusion Professor Ding E in treating knee osteoarthritis cold arthralgia patients by traditional Chinese medicine fumigation have a good clinical efficacy.