噻托溴铵联合康复锻炼对COPD稳定期患者血清IL-8、肺功能及生活质量的影响

Effects of tiotropium bromide combined with rehabilitation exercise on serum IL-8,lung function,and the quality of life in patients with stable COPD

目的:探讨噻托溴铵联合康复锻炼对慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)稳定期患者血清IL-8、肺功能及生活质量的影响。方法:选取2014年2月至2015年2月在我院就诊的84例COPD稳定期患者作为研究对象,按随机数字表法将其分为对照组和观察组,每组各42例。对照组患者予以口服氨茶碱释缓片、噻托溴铵吸入进行治疗,观察组患者在此基础上加用康复锻炼,治疗一个月后,比较两组患者血清IL-8、第1s用力呼气量(Forced expiratory volume in the first second,FEV1)、第1s用力呼气容积占预测值百分比(Forced expiratory volume in the first second/forced vital capacity,FEV1/FVC)、生活质量等指标。结果:(1)两组患者治疗后血清IL-8水平较治疗前明显降低,且观察组降低程度明显大于对照组(P<0.05);(2)两组患者治疗后FEV1、FEV1/FVC等肺功能指标均较治疗前提高,且观察组提高程度明显大于对照组(P<0.05);(3)两组患者治疗后生理机能比较无明显差异(P>0.05),观察组患者生理职能、躯体疼痛、一般健康、精力、社会功能、情感职能以及精神健康评分均高于对照组(P<0.05)。结论:噻托溴铵联合康复锻炼对COPD稳定期患者具有良好的临床疗效,优于单纯噻托溴铵治疗,可有效改善患者血清IL-8、肺功能指标,提高患者生活质量,值得临床推广应用。

Objective：To investigate the effects of tiotropium combined with rehabilitation on serum IL-8,pulmonary function,and the quality of life in patients with stable chronic obstructive pulmonary disease（COPD）.Methods：Eighty-four patients with stable COPD admitted to our hospital from February 2014 to February 2015 were enrolled as the study subjects,and randomly divided into the control group and the observation group with 42 cases in each group.Patients of the control group were given oral aminophylline tablets and tiotropium inhalation therapy.On the basis of this,patients of the observation group were treated with rehabilitation exercises.After one month of treatment,the levels of serum IL-8,FEV1,FEV1/FVC,and the quality of life were compared between the two groups.Results：After treatment,serum IL-8 levels in both groups were significantly lower than those before treatment.And the degree of decrease in the observation group was significantly greater than that in the control group（P〈0.05）.The pulmonary function indexes such as FEV1 and FEV1/FVC after treatment in both groups was higher than those before treatment.And the improvement in the observation group was significantly greater than that in the control group（P〈0.05）.There was no significant differences in the physiological function between the two groups after treatment（P〈0.05）.The physical function,physical pain,general health,energy,social function,emotional function,and mental health of the observation group were better than those of the control group（P〈0.05）.Conclusion：Tiotropium combined with rehabilitation exercise has good clinical efficacy in patients with stable COPD and is better than tiotropium alone.It can effectively improve the patient＇s serum IL-8,pulmonary function indicators,the quality of life,which is worthy of clinical promotion and application.