慢性阻塞性肺疾病急性加重期伴肺炎患者血清IL-6、HPT、SAA的检测价值分析

The anaylsis of value of serum IL-6,HPT and SAA in patients with acute exacerbation of chronic obstructive pulmonary disease with pneumonia

目的探讨慢性阻塞性肺疾病(COPD)急性加重期伴肺炎患者血清白介素-6(IL-6)、触珠蛋白(HPT)、淀粉样蛋白A(SAA)的检测价值。方法选自该院2015年12月至2017年3月收治的COPD急性加重期不伴肺炎患者87例及伴肺炎患者76例作为COPD不伴肺炎组和COPD伴肺炎组;另选自该院同期健康体检者62例作为对照组。比较3组血清IL-6、HPT和SAA水平变化,血清IL-6、HPT、SAA对COPD伴肺炎的诊断价值及IL-6、HPT和SAA的相关性。结果 COPD伴肺炎组血清IL-6、HPT和SAA水平高于COPD不伴肺炎组和对照组,且COPD不伴肺炎组血清IL-6、HPT和SAA水平高于对照组,差异均有统计学意义(P<0.05);IL-6、HPT、SAA联合诊断特异度、敏感度和阳性预测值高于IL-6、HPT、SAA单项诊断,差异有统计学意义(P<0.05);IL-6与HPT、SAA呈正相关,HPT与SAA呈正相关。结论 COPD急性加重期伴肺炎患者血清IL-6、HPT和SAA水平升高,三者联合诊断具有较高的敏感度和特异度,且IL-6、HPT和SAA水平呈正相关。

Objective To investigate the value of serum interleukin-6（IL-6）,haptoglobin（HPT）and amyloid A（SAA）in patients with acute exacerbation of chronic obstructive pulmonary disease（COPD）with pneumonia.Methods 87 cases of acute exacerbation of COPD without pneumonia and 76 cases with pneumonia,admitted in the hospital from December 2015 to March 2017,were selected as COPD without pneumonia group and COPD with pneumonia group.62 healthy people who underwent the healthy assessment during the same period were selected as the control group.The changes of serum IL-6,HPT and SAA levels in three groups,the value of serum IL-6,HPT and SAA levels in detecting COPD with pneumonia and the correlation of IL-6,HPT and SAA were compared.Results COPD patients with serum IL-6,HPT and SAA were higher than group COPD with pneumonia group and control group,and COPD is not associated with serum IL-6,HPT and SAA in pneumonia group than the control group（P〈0.05）;IL-6＋HPT＋SAA diagnostic specificity,sensitivity and positive predictive value is higher than IL-6,HPT and SAA（P〈0.05）;IL-6 and HPT was positively related with SAA and HPT was positively correlated with SAA.The serum levels of IL-6,HPT and SAA in the COPD with pneumonia group were higher than those in the COPD without pneumonia group and the control group,and the serum IL-6,HPT and SAA levels in the COPD without pneumonia group were higher than those in the control group,and the difference was statistically significant（P〈0.05）.The diagnostic specificity,sensitivity and positive predictive value of the combined detection of IL-6,HPT and SAA levels were higher than those of single detection of IL-6,HPT and SAA level,and the difference was statistically significant（P〈0.05）;IL-6 level was positively correlated with HPT and SAA levels,and HPT was positively correlated with SAA level.Conclusion The levels of serum IL-6,HPT and SAA in patients with acute exacerbation of COPD increased.The combined detection of the three had relatively high sensitivity and specificity,and the levels of IL-6,HPT and SAA were positively correlated.