结肠癌患者脂代谢特征及其临床价值

Characteristics of lipid metabolism in patients with colon cancer

目的探讨结肠癌患者脂代谢特征及其临床价值。方法回顾已确诊74例结肠癌患者的术前血TC、TG、HDL-C和LDL-C,并按照性别、年龄、手术记录、术后标本病理报告及2年内有无进展将患者分为不同性别组(男性组与女性组),不同年龄组(≤60岁组与>60岁组),不同发病部位组(左半结肠组与右半结肠组),不同疾病分期组(II期组与III期组),2年无进展生存时间(PFS)(2年内未进展组与2年内进展组)。对收集的数据使用SPSS19软件进行统计学分析。结果 74例患者中TG升高14例(18.92%),正常60例(81.08%),降低0例(0%);TC升高24例(32.43%),正常50例(67.57%),降低5例(6.76%);HDL-C正常68例(91.89%),降低6例(8.11%);LDL-C升高15例(20.27%),正常59例(79.73%)。患者血脂及脂蛋白在不同年龄、肿瘤分期、发生部位之间无统计学差异,不同性别与HDL之间有统计学差异,与TG、TC、LDL之间无统计学差异,TC与LDL的血清浓度高低对结肠癌患者2年内疾病进展之间有统计学差异。结论结肠癌患者血清TC、LDL水平与疾病进展的关系较为密切。结肠癌的发生、发展与脂代谢有密切关联,血清中血脂水平检测有利于结肠癌的诊断与治疗,并有一定的预后提示意义。

Objective To analyze the characteristics of lipid metabolism in colon cancer patients. Methods The total cholesterol（TC）, triglyceride（TG）, high-density lipoprotein cholesterol（HDL-C）, and low density lipoprotein（LDL-C） were measured in 74 patients with colon cancer before surgery. Patients were stratified by sex（male and female）, age（≤ 60 and 60 years）, tumor site（left colon and right colon）, disease stage（stage II and stage III）, 2-year progress-free survival（PFS）（no progress within 2 years and progress within 2 years）. SPSS19 was used for analysis. Results Among 74 patients included, 59 cases were followed up for more than two years. There were no significant differences in the levels of lipids and lipoproteins among patients with different age, tumor stage and tumor lesion. However, there was a statistical difference in HDL-C between male and female patients; and in serum concentration of TC（Log Rank P=0.005） and LDL-C（Log Rank P=0.013） between patients with disease progression in two years and without progression. Conclusion In our study, the serum TC and LDL-C level in patients with colon cancer are closely associated with the progression of the disease.