早发或晚发抑郁症住院患者临床特征研究

Clinical characteristics of early-onset and late-onset inpatients with depression

目的比较早发(发病年龄≤25岁)与晚发(发病年龄>25岁)抑郁症住院患者的临床特征及相关因素。方法回顾性分析472例抑郁症重度发作患者,对早发和晚发抑郁症患者人口学及病史资料进行比较。相关数据分别采用Mann-Whitney检验、卡方检验、多元Logistic回归和协方差分析。结果早发组114例,晚发组358例。与晚发组相比,早发组病程更长,发作次数更多,更多患者无配偶、无业,较少伴有慢性躯体合并症,更多使用心境稳定剂(P<0.01)。多元回归分析显示,早发抑郁证与无配偶、无业、更多使用心境稳定剂、长病程有关(P<0.01)。结论早发抑郁与晚发抑郁的临床特征有显著差异,疾病危害更明显。

Objective To compare the differences of the clinical characteristics and correlated factors between early-onset and late-onset inpatients with depression. Methods A retrospective analysis of 472 patients with severe episodes of depression was conducted to compare the demographic and medical history of patients with early-onset and late-onset depression. The relevant data were analyzed by Mann-Whitney test,chi-square test,multivariate logistic regression and covariance analysis,respectively.Results There were 114 cases in the early-onset group and 358 cases in the late-onset group. Compared with the late-onset group,the early-onset group had a longer disease duration and more episodes. More patients had no spouse or no job,and fewer were associated with chronic physical complications. More patients used mood stabilizers（ P〈0. 01）. Multiple regression analysis showed that premature depressive symptoms were associated with mateless,unemployment,more use of mood stabilizers,and longer disease duration（ P〈0. 01）. Conclusion There are significant differences in the clinical features of early-onset depression and late-onset depression,and the impact of early-onset depression is the more serious.