奥美拉唑、奥曲肽治疗消化性溃疡和上消化道出血的疗效

Omeprazole and Octreotide for the Treatment of Peptic Ulcer and Upper Gastrointestinal Hemorrhage

目的比较奥美拉唑及奥曲肽联合治疗60例消化性溃疡合并上消化道出血患者的效果。方法选择2015年1月—2018年1月于我院就诊的消化性溃疡合并上消化道出血患者,共60例,按入院编号随机分为两组,每组30例。对照组仅给予奥美拉唑治疗,观察组采用奥美拉唑和奥曲肽治疗,对比两组患者的治疗效果。结果对照组治疗总有效率低于观察组,不良反应多且止血时间长、再出血发生率高,差异具有统计学意义(P<0.05)。结论在治疗消化性溃疡合并上消化道出血时,联合采用奥美拉唑和奥曲肽有助于促进治疗效果的显著增强,减少不良反应。

Objective To compare the efficacy of omeprazole and octreotide in the treatment of peptic ulcer associated with upper gastrointestinal hemorrhage. Methods A total of 60 patients with peptic ulcer complicated with upper gastrointestinal hemorrhage who were admitted to our hospital from January 2015 to January 2018 were selected and randomly divided into two groups according to the admission number. Each group included 30 patients. The control group received omeprazole alone, and the observation group used omeprazole and octreotide. The effect was compared between the two groups. Results The total effective rate of treatment in the control group was lower than that in the observation group. The adverse reactions were more numerous and the time for hemostasis was longer and the incidence of rebleeding was higher, which was statistically significant（P 0.05）. Conclusion In the treatment of peptic ulcer combined with upper gastrointestinal hemorrhage, the combination of omeprazole and octreotide can significantly improve the therapeutic effect and reduce adverse reactions.