耳穴埋豆加溃结膏穴位贴敷联合柳氮磺胺吡啶对溃疡性结肠炎的疗效观察

Clinical Observation on Auricular Acupuncture Point Bean Combined with Kuijie Gao Acupoint Application and Sulfasalazine in Preventing Recurrence of Ulcerative Colitis

目的探讨耳穴埋豆联合溃结膏穴位贴敷与柳氮磺胺吡啶对溃疡性结肠炎的疗效情况。方法选取溃疡性结肠炎患者88例(本院门诊2016年1月至2016年12月收治),电脑随机分成观察组44例、对照组44例,对照组给予柳氮磺胺吡啶治疗,观察组给予耳穴埋豆联合溃结膏穴位贴敷联合柳氮磺胺吡啶治疗,比较两组患者临床疗效情况。结果观察组治疗后1、2个月复发率2.27%、6.82%,显著低于对照组对应时间复发率(P<0.05),差异有统计学意义;治疗后两组患者临床症状评分均显著改善,观察组和对照组有显著性差异(P<0.05),差异有统计学意义;治疗后,两组结肠观察评分均显著改善,观察组较对照组有显著性差异(P<0.05);治疗后两组患者黏膜菌群均较治疗前有显著性改善,但两组间无显著性差异;观察组临床有效率95.45%(42例),对照组临床有效率59.09%(26例),观察组显著高于对照组(χ2=16.5647,P<0.05),有统计学意义。结论给予溃疡性结肠炎患者应用耳穴埋豆联合溃结膏穴位贴敷与柳氮磺胺吡啶方案治疗,可显著改善患者临床症状、肠道黏膜菌群,并且对于降低病情复发率也有显著性意义。

Objective To investigate the therapeutic effect of auricular acupoint burying with acupoint application and sulfasalazine on preventing the recurrence of ulcerative colitis. Methods Eighty-eight patients with ulcerative colitis were selected（ according to our hospital from January 2016 to December 2016）.The patients were randomly divided into observation group（ 44 cases） and control group（ 44 cases）. The control group was given sulfasalazine,and the observation group The acupuncture and burying beans combined with acupoint application combined with sulfasalazine were used to compare the clinical efficacy of the two groups. Results The recurrence rate was 2. 27 % and 6. 82 % in the observation group one month and two months after treatment,which was significantly lower than the corresponding time relapse rate in the control group（ P〈 0. 05）. There was significant difference between the two groups. The clinical symptom scores of the two groups were significantly improved after treatment. There was a significant difference between the observation group and the control group（ P〈 0. 05）,with statistical significance; after the treatment,the colon observation scores of the two groups were significantly improved,and there was a significant difference between the observation group and the control group（ P〈 0. 05）; The mucosal flora was significantly improved compared with that before treatment,but there was no significant difference between the two groups（ P〉 0. 05）. The clinical effective rate was 95. 45 %（ 42 cases） in the observation group and 59. 09 %（ 26 cases） in the control group. The clinical effectiveness of the group was significantly higher than that of the control group（ χ2=16. 5647,P〈 0. 05）,which was statistically significant. Conclusion The treatment of patients with ulcerative colitis with auricular acupuncture combined with Kuijie Gao acupoint application and sulfasalazine treatment can significantly improve the clinical symptoms and intestinal mucosal flora of patients,and it also has significant significance in reducing the recurrence rate of the disease.