小檗碱片联合二甲双胍治疗2型糖尿病效果评价

Effectiveness Evaluation Analysis on Berberine Tablets Combination with Metformin Treating Type2 Diabetes

目的探讨小檗碱片联合二甲双胍治疗2型糖尿病(T2DM)的临床效果。方法将80T2DM患者随机分为对照组和治疗组,每组40例;对照组给予单纯二甲双胍治疗,而治疗组在此基础上增加盐酸小檗碱治疗;治疗3个月后,比较两组患者的血糖水平、HOMA-β、HOMA-IR、炎症因子水平等指标。结果治疗后,治疗组的FPG、2h PG、Hb A1c水平均明显低于对照组(P<0.05);治疗组的HOMA-β、HOMA-IR水平均明显低于对照组(P<0.05);治疗组的CRP、IL-6及TNF-α水平均明显低于对照组(P<0.05)。结论 T2DM患者实施小檗碱片联合二甲双胍治疗后,可减轻炎性反应,促进胰岛素β细胞分泌,提高细胞胰岛素敏感性,从而实现多样化降血糖作用。

Objective To explore the clinical effect of Berberine tablets combination with Metformin treating type 2 diabetes（ T2 DM）. Methods Of 80 cases of T2 DM were randomly divided into control group and treatment group,40 cases each group. The control group was given the treatment of Metformin,and the treatment group was given an additional treatment of Berberine tablets. After 3 months treatment,the indexes of blood sugar levels,HOMA-β,HOMA-IR and inflammatory factor were compared between the two groups. Results After treatment,the levels of FPG,2 h PG and Hb A1 c in the treatment group were all obviously lower than the control group（ P〈0. 05）. The indexes of HOMA-β and HOMA-IR in the treatment group were lower than the control group（ P〈0. 05）. And the levels of CRP,IL-6 and TNF-α in the treatment group were all lower than the control group（ P〈0. 05）. Conclusion The treatment of Berberine tablets combination with Metformin could alleviate inflammatory response,promote secretion of insulin βcell,increase cell insulin sensitivity and achieve a variety of hypoglycemic effect.