MSCT全肿瘤灌注参数与结直肠癌临床病理分期及MVD、EGFR水平的相关性

Correlation between MSCT whole-tumor perfusion parameters and clinicopathological staging and MVD and EGFR levels in colorectal carcinoma

目的探讨多层螺旋CT(MSCT)全肿瘤灌注参数与结直肠癌临床病理分期及肿瘤微血管密度(MVD)、表皮生长因子受体(EGFR)表达水平的相关性。方法以MSCT全肿瘤灌注的42例结直肠癌为研究对象,记录患者灌注参数(血容量(BV)、血流量(BF)、达峰时间(TTP)、表面通透性(PS)),根据病理诊断结果患者进行临床病理分期,并按照免疫组化步骤检测肿瘤样本中MVD及EGFR表达情况,采用person相关性分析或Spearman相关性分析检测灌注参数与其他指标的相关性。结果根据病理结果,分别有6例、7例、14例、15例患者中处于TNM的Ⅰ、Ⅱ、Ⅲ、Ⅳ期;且TNM分期与BV、BF、TTP具有一定相关性(r BF=-0.683,P=0.023;r TTS=0.632,P=0.035;r PS=0.654,P=0.035);此外MVD及EGFR与以上各参数无明显相关性(P>0.05),但MVD与EGFR之间存在一定相关性(r=0.433,P=0.043),同时,EGFR阴性组与阳性组在BF、TTS表达差异差异存在统计学意义(P<0.05)。结论 MSCT全肿瘤灌注参数与临床病理分期具有较好的相关性,而MVD及EGFR与相关性较差,因而较适宜作为临床病理特征分析的辅助指标。

Objective To investigate the relationship between the perfusion parameters of MSCT and clinical stage,colorectal cancer,microvessel density（MVD） and epidermal growth factor receptor（EGFR） expression in colorectal cancer. Methods The blood perfusion parameters（blood volume（BV）,blood flow（BF）,peak time（TTP） were recorded in 42 patients with colorectal cancer who were treated with MSCT in our hospital from 2014 to 2016. The expressions of MVD and EGFR in tumor samples were detected by immunohistochemical method. The correlation between the expression of MVD and EGFR was analyzed by person correlation analysis or Spearman correlation analysis. Results According to the pathological results,there were 6 cases,7 cases,14 cases and 15 cases in TNM stage Ⅰ,Ⅱ,Ⅲ,Ⅳ; TNM staging and BV,BF,TTP has a certain correlation（r BF =-0. 683,P = 0. 023; r TTS = 0. 632,P = 0. 035; r PS = 0. 654,P = 0. 035）,in addition,MVD and EGFR had no correlation with the above parameters（P〈0. 05）,but there was a correlation between MVD and EGFR（r = 0. 433,P = 0. 043）.Meanwhile,these was a significant difference between EGFR negative group and positive group（P〈0. 05）. Conclusion There is a good correlation between the parameters of MSCT and the clinical pathological stage,but MVD and EGFR are poorly correlated,so they are more suitable for the clinicopathological characteristics.