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地特胰岛素联合瑞格列奈治疗2型糖尿病的临床对照研究 被引量:3

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摘要 目的研究联合应用地特胰岛素及瑞格列奈治疗2型糖尿病的效果。方法选取2014年3月—2017年3月期间该院收治的80例2型糖尿病患者作为该次研究对象,按照患者入院先后顺序,将患者分为实验组和对照组,其中对照组采用中性低精蛋白锌人胰岛素治疗,实验组则联合应用地特胰岛素及瑞格列奈治疗,比较治疗效果。结果治疗前后,两组患者的FPG、2 hPG、HbAlc指标水平比较,组间数据差异无统计学意义(P>0.05);治疗后,两组患者患者的FPG、2 hPG、HbAlc指标水平均明显低于治疗前,两组均取得了良好的治疗效果,且治疗前后数据差异有统计学意义(P<0.05)。结论 2型糖尿病联合应用地特胰岛素及瑞格列奈治疗具有安全有效的特点,且降低了低血糖等不良事件的发生率,值得推广。
作者 严丽琼
出处 《糖尿病新世界》 2018年第1期59-60,共2页 Diabetes New World Magazine
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  • 1俞璐,罗敏.氧化应激与糖尿病血管并发症[J].国外医学(内分泌学分册),2005,25(6):396-398. 被引量:16
  • 2Philis-Tsimikas A, Charpentier G, Clauson P, et al. Comparison of once daily insulin detemir with NPH insulin added to a regimen of oral antidiabetic drugs in poorly controlled type 2 diabetes. Clin Ther, 2006, 28:1569-1581.
  • 3Hermansen K, Davies M, Derezinski T, et al. A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetes Care, 2006, 29:1269-1274.
  • 4Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA, 2006, 295..1681-1687.
  • 5Hennige AM, Sartorius T, Tschritter O, et al. Tissue selectivity of insulin detemir action in vivo. Diabetologia, 2006, 49: 1274-1282.
  • 6Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes[ J ] . JAMA, 2006, 295 (14) : 1681-1687.
  • 7Monnier L,Colette C,Owens DR. Integrating glycaemic variability in the glyeaemic disorders of type 2 diabetes : a move towards a unified glucose tetrad concept[ J ] . Diabetes Metabolism Research and Reviews, 2009, 25 (5) : 393-402.
  • 8Piconi L, Quagliaro L, Da Ros R, et al. Intermittent high glucose en- hances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture : the role of poly ( ADP-ri- bose ) polymerase [ J ]. Thromb Haemost,2004,2 ( 8 ) : 1453-1459.
  • 9Quagliaro L, Piconi L, Assaloni R, et al. Intermitenthigh glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells : therole of protein kinase C and NAD (P) H-oxidase activation [ J ] . Diabetes ,2003 ,52 ( 11 ) : 2795-2804.
  • 10Cryer PE, Davis SN, Shamoon H. Hypoglycemia in diabetes. Diabetes Care, 2003, 26:1902-1912.

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