胃黏膜靶向活检技术的研究进展

Gastric mucosal targeted biopsy:A review of research progress

胃癌是全球第五大常见恶性肿瘤,由于肿瘤病灶分布不均一和常规活检的随机性,使得常规活检不能精确、有效地取到病灶组织,存在一定程度的漏诊。目前,临床前及临床应用靶向活检技术提高早期癌变及癌前病变诊断的精确性。靶向活检技术是通过色素内镜、电子染色内镜、共聚焦显微内镜(confocal microscopic endoscopy,CLE)、高分辨率显微内镜(high-resolution microendoscopy,HRME)诊断技术对胃黏膜病变进行细胞结构的实时在体成像,对目标病变进行靶向活检,提高了消化道早期癌变病灶的检出率。本文就靶向活检技术在消化道早癌诊断中的研究进展作一综述。

Gastric cancer is the fifth most common malignancy in the world. Due to the uneven distribution of tumor lesions and the randomness of routine biopsy, it is impossible to accurately and effectively obtain the lesion tissue and is likely to be misdiagnosed. At present, the accuracy of early canceration and precancerous lesion diagnosis is boosted using the targeted biopsy techniques in preclinic and clinic. The targeted biopsy technique is capable of performing real-time image in vivo and carrying out targeted biopsy to target lesions and can improve the detection rate of early cancerous lesions in the digestive tract based on new endoscopy diagnostic techniques such as pigmented endoscopy, electronic staining endoscopy, confocal microscopic endoscopy（CLE）, and high-resolution microendoscopy（HRME）. This paper reviews the research progress of targeted biopsy in the diagnosis of early gastrointestinal cancer.