补肾宣郁法干预肾虚肝郁型卵巢储备功能减退患者临床疗效观察

Clinical curative effect observation on kidney nourishing ventilating depression therapy for the treatment of the kidney deficiency and liver stagnation of decline in ovarian reserve

[目的]观察补肾宣郁方益经滋癸饮治疗肾虚肝郁型卵巢储备功能减退患者的临床疗效。[方法]选择中、西医诊断符合肾虚肝郁型卵巢储备功能减退患者70例,随机分为治疗组和对照组各35例,分别给予益经滋癸饮颗粒剂及坤宝丸治疗,嘱患者自月经期第5天开始服用,早晚各服1次,持续3个月为1个疗程,月经期停药。观察治疗组与对照组临床症状积分变化,电化学发光法测定血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)水平。[结果 ]两组患者治疗后血清FSH、LH均较治疗前降低(P<0.05或P<0.01),对照组患者治疗后血清E2较治疗前降低(P<0.05);治疗后两组患者血清FSH、LH、E2比较无统计学差异(P>0.05);治疗组临床疗效评价优于对照组(P<0.05)。[结论]补肾宣郁型方药益经滋癸饮在治疗肾虚肝郁型卵巢储备功能减退方面优于中成药坤宝丸。

[Objective] To observe the effect of kidney nourishing ventilating depression therapy with Yijing Zigui yin for the treatment ofthe kidney deficiency and liver stagnation of decline in ovarian reserve. [Methods] According to the diagnosis of Western medicine andChinese medicine meet of decline in ovarian reserve of the liver kidney deficiency in patients with a total of 70 cases, the computerrandomly divided into treatment group and control group with 35 cases in each group, respectively, by Yijing Zigui yin treatment groupand Kunbao pill control group. Patients were instructed to start taking from the menstrual period fifth days, morning and evening andlasting for 3 months for a course of treatment, next menstrual period withdrawal. To observe the treatment group and the control groupclinical symptom score changes, the determination of serum follicle stimulating hormone （FSH）, luteinizing hormone （LH）, estradiol （E2）level, safety index and pregnancy rate. [Results] Serum FSH and LH levels in both groups decreased after treatment （P〈0.05 or P〈0.01）,serum E2 level decreased after treatment in patients in the control group （P〈0.05）, there was no statistical difference in serum FSH, LH, E2between the two groups after treatment （P〉0.05）, the clinical efficacy of the treatment group was better than the control group （P〉0.05）.[Conclusion] The treatment effect of decline in ovarian reserve of the kidney deficiency and liver stagnation in treatment of kidneynourishing ventilating depression therapy Yijing Zigui yin was better than Chinese patent medicine Kunbao pills.