摘要
目的考察不同包材对复方薄荷脑滴鼻液中薄荷脑、樟脑含量的影响。方法采用大口径HP-FFAP交联弹性石英毛细管柱为色谱柱,气相色谱法测定。考察在同一存放条件下低密度聚乙烯、聚丙烯、聚酯和玻璃封装的滴鼻液中两种成分的含量变化情况。结果在4种包材中,制剂中2种成分均会随时间延长而减少。结论不同包材对制剂中两种成分有一定影响,初步确定聚丙烯瓶更适于灌装复方薄荷脑滴鼻液。
Objective To explore the effects of different packaging materials on the contents of menthol and camphor in compound menthol nasal drops. Methods Menthol and camphor were determined by GC with heavy-gauge HP-FFAP capillary column as chromatographic column. The contents change of the two components in nasal drops of low density polyethylene( LDPE),polypropylene( PP),polyester( PET) and glass were investigated under the same storage condition. Results Contents of the two components in the preparation were decreased with time in 4 different packaging materials. Conclusion Different packaging materials have some effects on contents of the two components.It is preliminarily determined that PP was more suitable for menthol nasal drops.
作者
杨雪
马虹英
YANG Xue;MA Hongying(Department of Pharmacy,Xiangya Hospital,Central South University,Changsha 410000,China)
出处
《医药导报》
CAS
北大核心
2018年第7期873-875,共3页
Herald of Medicine
关键词
樟脑
薄荷脑
包材
稳定性
Camphor;Menthol;Packaging materials;Stability