前列安栓与安慰剂对照治疗慢性前列腺炎的系统评价

Systematic evaluation of Prostant TM and placebo in the control treatment of chronic prostantits

目的系统评价前列安栓与安慰剂对照治疗慢性前列腺炎(CP)的有效性与安全性。方法计算机检索Pub Med、万方、中国期刊全文数据库(CNKI)、维普全文数据库(VIP)及中国学位论文全文数据库中相关文献,检索时间为2000年1月至2017年5月。铺以手工检索,2位研究者根据纳入与排除标准独立筛选文献、提取资料并评价文献质量。用Rev Man5.0软件对各效应指标进行meta分析。结果纳入7篇文献,研究病例数共计1 090例。前列安栓(试验组)与安慰剂(对照组)治疗后美国国立卫生研究院慢性前列腺炎症状指数评分比较,差异有统计学意义[P=0.02,均数差=-1.34,95%置信区间(95%CI)-2.48^-0.20];两组治疗后总显效率比较,差异有统计学意义(P<0.001,合并比值比=3.11,95%CI 2.34~4.12);两组主要不良反应(肛门不适及排便感、腹痛腹泻、肛门出血、腹胀及肛门不适兼腹泻)发生率比较,差异无统计学意义(P>0.05)。结论前列安栓治疗CP安全、效果显著,值得临床推广使用。

Objective To systematic evaluation the effectiveness and safety of Prostant^TM and placebo in the control treatment of chronic prostatitis （CP）. Methods Computer retrieved of PubMed, Wanfang, CNKI, and VIP and China＇ s disser-tation full text database, retrieval time was January 2000 to May 2017. Based on manual retrieval, two researchers independent-ly screened the literature, extracted the data and evaluated the quality of the literature according to the inclusion and exclusion criteria. The effect indexes were meta-analyzed with RevMan5.0 software. Results A total of 1 090 cases were studied in 7 lit-eratures. Compared with the placebo （control group）, the results showed that there was a statistically significant difference of the national institutes of health chronic prostate inflammation index after treatment in the ProstantTM （experimental group） （P= 0.02, MD=-1.34,95%CI -2.48--0.20） ;the total efficiency after treatment between two groups was compared, the difference was statistically significant （P〈0.001, OR,ORmerge=3.11,95%Cl 2.34-4.12） ;main adverse reactions （anal discomfort and defecation, abdominal pain and diarrhea, anal bleeding, abdominal distension and anal discomfort and diarrhea） rate of two groups were compared, the differences were not statistically significant （P〉0.05）. Conclusion Pl＇ostantTM is safe and effective in the treat- ment of CP, greatly improve the clinical symptoms, is worth wide use in the clinical.