具有近红外三阶非线性光学性质的咪唑邻菲罗啉钌配合物的合成及其与DNA作用特性

A Novel Third-Order Non-Linear Optical Ruthenium( Ⅱ)Complex Based on Imidazo-phenanthroline Derivative:Design,Synthesis and DNA Binding Properties

以邻菲罗啉双酮和N,N-二(4-丁氧基苯基)氨基苯甲醛为原料,设计合成了光功能配体(L)及其钌配合物1,运用现代分析测试手段进行了表征。利用开/闭孔Z扫描技术测试了目标化合物的三阶非线性光学性质。结果表明,在近红外范围内钌配合物具有比配体更大的三阶非线性系数和双光子吸收截面。通过UV-Vis吸收光谱、荧光光谱、圆二色光谱和粘度实验,研究了配合物与小牛胸腺DNA结合特性。结果表明,配合物通过插入模式与DNA结合。因此,该新型钌配合物可以作为非线性光学材料应用于生物显影。

A new D-π-A type two-photon absorption ligand（ L） based on imidazo [4,5-f][1,10]phenanthroline and its Ru（Ⅱ） complex（ 1） have been synthesized and characterized. The third-order nonlinear optical（ NLO） properties of all compounds are studied by open/close aperture Z-scan techniques. The results reveal that complex 1 possesses larger third-order nonlinear susceptibility and two-photon absorption cross section than its free ligand L in the near infrared range. A reverse nonlinear optical refraction character takes place from self-defocusing to self-focusing response after complexation. Calf-thymus DNA binding properties combined with complex 1 are studied by UV-Vis absorption,DNA competitive binding with ethidium bromide,viscosity measurements,and circular dichrosim spectra. The results indicate that complex 1 binds to DNA via an intercalative mode. Therefore,the complex 1 with nonlinear optical properties can be used for bioimaging applications.