从神经内分泌角度探讨肝主疏泄调畅情志的现代理论内涵

From the perspective of neuroendocrine to explore the modern theoretical connotation of “liver governing and dispersing and regulating emotions”

肝在情志活动变化中占有不可忽视的地位,肝是中枢系统调节下多器官、多靶点的自适应调节系统,肝主疏泄的中枢神经生物学机制是在整体上与调节下丘脑-垂体-肾上腺(hypothalamic-pituitary-adrenal axis,HPA)轴及下丘脑-垂体-甲状腺(hypothalamic-pituitary-thyroid,HPT)轴相关。体内激素稳态水平的微变化负反馈于下丘脑,通过大脑皮层整合表现为情志变化,是肝主疏泄调畅情志的实质。正确理解肝主疏泄调畅情志的内涵对情感活动障碍性疾病的病因、诊断、治疗与预防养生,都具有指导意义。

Liver plays an important role in the change of emotional activities. The liver is an adap- tive regulation system of multiple organs and multiple targets regulated by the central nervous system. The central neurobiological mechanism of liver governing dispersing and discharging is related to regulating the hypothalamic-pituitalT-adrenal axis and hypothalamicpituitalT-thyroid, The micro change of hormone in the body is negatively related to the hypothalamus, and is manitested as emotional changes through the integra- tion of the cerebral cortex, which is the essence of the liver controlling dispersion and regulating emotion. A ton＇cot understanding of the connotation of liver governing and dispersing emotions is of guiding significance for the etiology, diagnosis, treatment and prevention of health disorders.