期刊文献+

一测多评法同时测定穿心莲分散片中4种内酯类成分的含量 被引量:2

Determination of Four Lactones in Chuanxinlian Dispersable Tablets by QAMS
下载PDF
导出
摘要 目的:采用"一测多评法"(QAMS)同时测定穿心莲分散片中4种内酯类成分的含量,并验证本方法在穿心莲分散片质量控制中的应用价值。方法:以穿心莲内酯为参照物,建立其与新穿心莲内酯、去氧穿心莲内酯和脱水穿心莲内酯之间的相对校正因子;采用外标法测定穿心莲内酯的含量,通过相对校正因子计算新穿心莲内酯、去氧穿心莲内酯和脱水穿心莲内酯的含量,对一测多评法的计算值与外标法实测值进行比较。结果:各相对校正因子重现性良好,各成分利用相对校正因子计算的量值与外标法测定值之间无显著差异。结论:该方法准确可靠,简便可行,且节约对照品及检测成本,该方法可作为穿心莲分散片的多指标成分测定质量控制方法。 Objective: To determine the contents of four kinds of lactones in Chuanxinlian Dispersable Tablets under Quality Assurance Management System( QAMS),and to verify the application value of AQMS in quality control of Chuanxinlian Dispersable Tablets. Methods: Taking andrographolide as the reference,the relative correction factor( RCF) between it and new andrographolide,deoxyandrographolide,as well as dehyandrographolide were established.The content of andrographolide was determined with external standard method; furthermore,the contents of new andrographolide,deoxyandrographolide and dehyandrographolide were caculated by RCF. The value obtained by external standard method and the value obtained by AQMS were compared. Results: The RCF has good repeatability. There were no significant difference between the values obtained by the two different methods. Conclusion: QAMS is accurate and feasible to economically evaluate the quality of Chuanxinlian Dispersable Tablets.
作者 姜志远 刘世萍 马妍妍 李业雨 JIANG Zhiyuan;LIU Shiping;MA Yanyan;LI Yeyu(Disease Control and Prevention Center,Heilongjiang Farms & Land Reclamation Administration,Harbin 150090,China;Pharmacy Department,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处 《中医药学报》 CAS 2018年第4期54-57,共4页 Acta Chinese Medicine and Pharmacology
关键词 一测多评 穿心莲分散片 内酯类成分 相对校正因子 QAMS Chuanxinlian Dispersable Tablets Lactones Relative correction factor
  • 引文网络
  • 相关文献

参考文献6

二级参考文献32

共引文献519

同被引文献22

引证文献2

二级引证文献18

;
使用帮助 返回顶部