苏黄止咳胶囊联合匹多莫德对咳嗽变异性哮喘患儿诱导痰指标及气道功能的影响

Effects of Suhuang Zhike Capsule Combined with Pidotimode on Induced Sputum Indexes and Airway Function in Children with Cough Variant Asthma

目的:探讨苏黄止咳胶囊联合匹多莫德对咳嗽变异性哮喘(CVA)患儿诱导痰指标及气道功能的影响。方法:选取105例CVA患儿进行前瞻性随机对照研究,采用随机数字表法将患儿分为试验组(53例)和对照组(52例),入院后在常规治疗的基础上对照组加用匹多莫德口服液,试验组在对照组的基础上联合应用苏黄止咳胶囊,两组均连续服用1个月。比较两组临床疗效及治疗前后中医症候积分变化,检测并比较两组诱导痰指标水平及气道功能变化,观察治疗期间两组药物不良反应发生情况。结果:治疗后两组鼻塞、咳嗽、咽痒、气急评分评分均较治疗前降低(P<0.01),且试验组低于对照组(P<0.05或P<0.01)。试验组总有效率(83.02%)明显高于对照组(65.38%)(P<0.05)。治疗后两组诱导痰中嗜酸性粒细胞百分比、ICAM-1、MMP-9、VEGF含量均较治疗前降低,且试验组低于对照组(P<0.01)。治疗后两组气道功能指标FVC、FEV1较治疗前升高,且试验组高于对照组(P<0.05或P<0.01),MMEF、FEF75%较治疗前降低,且试验组低于对照组(P<0.01)。对照组和试验组不良反应发生率差异无统计学意义(9.62%vs 15.09%,P>0.05)。结论:苏黄止咳胶囊联合匹多莫德可显著改善CVA患儿临床症状,治疗效果理想,可能与其降低局部组织炎性浸润,改善气道功能有关,且安全性较好。

Objective： To investigate the effects of Suhuang Zhike Capsule combined with Pidotimode on induced sputum indexes and airway function in children with cough variant asthma（ CVA）. Methods： 105 CVA children were randomized into the observation group（ n = 53） and the control group（ n = 52）. The control group was treated with routine medication and Pidotimode; on which basis,the observation group was also treated with Suhuang Zhike Capsule. Both groups were treated for one month. The clinical curative effect,TCM symptom scores,the levels of induced sputum indexes,airway function,and adverse reactions were observed and compared in the two groups. Results： The scores of nasal obstruction,cough,itchy throat,shortness of breath were lowered in the two groups after treatment（ P〈 0. 01）; the decrease of the observation group were more significant than those of the control group（ P〈 0. 05,P〈 0. 01）. The total effective rate of the observation group was 83. 02%,which was significantly higher than 65. 38% of the control group（ P〈 0. 05）. The percentage of eosinophils,the contents of ICAM-1,MMP-9 and VEGF in induced sputum were lowered in the two groups after treatment,and the levels of the above indexes of the observation group were much lower than those of the control group（ P〈 0. 01）. The FVC and FEV1 were elevated in the two groups after treatment,the elevations of the observation group were more significant than those of the control group（ P〈 0. 05,P〈 0. 01）; the MMEF and FEF were reduced in the two groups after treatment,the reductions of the observation group were more significant than those of the control group（ P〈 0. 01）. There was no statistical difference between the two groups in terms of adverse reactions（ 9. 62% vs 15. 09%,P〉 0. 05）. Conclusion： Suhuang Zhike Capsule combined with Pidotimod can significantly improve the clinical symptoms of CVA children with satisfactory effect,which may be associated with reducing local inflammatory infiltration and improving airway function. This therapy has good security.