干扰素雾化吸入辅助治疗对新生儿病毒性肺炎病程中炎症及应激反应的影响

Effect of adjuvant interferon aerosol inhalation on inflammatory response and stress response in neonatal viral pneumonia

目的:研究干扰素雾化吸入辅助治疗对新生儿病毒性肺炎病程中炎症及应激反应的影响。方法:选择我院2015年5月～2017年10月期间收治的病毒性肺炎新生儿作为研究对象,随机分为接受干扰素吸入联合常规对症治疗的IFN组、常规对症治疗的对照组。治疗前及治疗后7天时,测定血清中炎症细胞因子、应激介质的含量及外周血中炎症信号分子的表达量。结果:与组内治疗前比较,两组患者治疗后7天时血清中SP-A、sICAM1、suPAR、sTREM1、Copeptin、Ins、NE、8-iso-PG的含量以及外周血中Tim1、Tim3、TLR2、TLR4、NF-κB的mRNA表达量均显著降低且IFN组患者治疗后7天时血清中SP-A、sICAM1、suPAR、sTREM1、Copeptin、Ins、NE、8-iso-PG的含量以及外周血中Tim1、Tim3、TLR2、TLR4、NF-κB的mRNA表达量均显著低于对照组。结论:干扰素雾化吸入辅助治疗能够减轻新生儿病毒性肺炎病程中炎症及应激反应的激活程度。

Objective：To study the effect of adjuvant interferon aerosol inhalation on inflammatory response and stress response in neonatal viral pneumonia.Methods：The newborns with viral pneumonia who were treated in our hospital between May 2015 and October 2017 were selected as the research subjects and randomly divided into the IFN group who received interferon inhalation combined with routine symptomatic treatment and the control group who received routine symptomatic treatment The contents of inflammatory cytokines and stress mediators in serum as well as the expression of inflammatory signaling molecules in peripheral blood were measured before treatment and 7 dafter treatment.Results：Compared with those of same group before treatment,SP-A,sICAM1,suPAR,sTREM1,Copeptin,Ins,NE and 8-iso-PG levels in serum as well as Tim1,Tim3,TLR2,TLR4 and NF-κB mRNA expression in peripheral blood of both groups significantly decreased 7 dafter treatment,and SP-A,sICAM1,suPAR,sTREM1,Copeptin,Ins,NE and 8-iso-PG levels in serum as well as Tim1,Tim3,TLR2,TLR4 and NF-κB mRNA expression in peripheral blood of IFN group 7 dafter treatment were significantly lower than those of control group.Conclusion：Adjuvant interferon aerosol inhalation can reduce the activation of inflammatory response and stress response in neonatal viral pneumonia.