噻托溴铵联合布地奈德福莫特罗治疗慢性阻塞性肺疾病的临床疗效分析

Clinical efficacy of Tiotropium bromide combined with Bbu Di Ned Fumo Tero in the treatment of chronic obstructive pulmonary disease

目的观察噻托溴铵联合布地奈德福莫特罗治疗慢性阻塞性肺疾病(COPD)的临床疗效。方法纳入我院2015年3月—2016年3月门诊接诊的200例COPD患者,根据治疗方案的差异分为联合组和单一组,每组100例。给予单一组患者布地奈德福莫特罗治疗,联合组在布地奈德福莫特罗治疗基础上加用噻托溴铵,观察2组患者治疗效果。结果与单一组比较,联合组治疗有效率明显更高(P<0.05);治疗后,与单一组比较,联合组FVC、FEV_1、PEF水平大幅度提高,TGF-β、MMP-9、TIMP-1水平大幅度降低,差异均有统计学意义(P<0.05)。结论采用噻托溴铵联合布地奈德莫特罗治疗COPD效果确切,且能控制血清相关细胞因子,促进肺功能恢复,可在临床推广。

Objective To observe and analyze the clinical efficacy of tiotropium bromide combined with Bbu Di Ned Fumo Tero in the treatment of chronic obstructive pulmonary disease（COPD）. Methods a randomized controlled trial was conducted in 200 COPD patients who were admitted to our hospital in March 2015 ~2016 in March. According to the difference of treatment regimen,the enrolled patients were divided into combined group and single group,100 cases in each group.A single group of patients was given Bbu Di Ned Fumo Tero treatment,and the combined group was added with tiotropium bromide on the basis of Bbu Di Ned Fumo Tero＇s treatment. The therapeutic effects of the two groups were observed. Results compared with the single group,the effective rate of the combined group was significantly higher （P〈0.05）.After treatment,compared with the single group,the levels of FVC,FEV1 and PEF increased significantly in the combined group,while the levels of TGF-,MMP-9 and TIMP-1 decreased significantly（P〈0.05）. Conclusion tiotropium bromide combined with Bbu Di Ned Motro is effective in the treatment of COPD,and it can control serum related cytokines and promote lung function recovery.It can be popularized in clinic.