布地奈德联合沙丁胺醇治疗慢阻肺急性加重期50例的疗效

The effect of budesonide combined with salbutamol in the treatment of 50 patients with acute exacerbation of chronic obstructive pulmonary disease

目的:观察布地奈德联合沙丁胺醇治疗慢性阻塞性肺疾病(慢阻肺)急性加重期的临床效果。方法:收治慢阻肺急性加重期患者50例,采用布地奈德联合沙丁胺醇治疗方式,评估本组患者临床治疗效果、不良反应以及治疗前后的肺通气功能、呼吸困难评分。结果:本组患者临床治疗总有效率94.0%,不良反应发生率12.0%,治疗后其FVC、FEV_1、FEV_1/FVC、PEF、呼吸困难评分明显好于治疗前,差异有统计学意义(P<0.05)。结论:针对慢阻肺急性加重期患者采用布地奈德联合沙丁胺醇治疗可明显改善其肺功能与呼吸困难症状,具有良好的临床有效性与安全性。

Objective：To observe the clinical effect of budesonide combined with salbutamol in the treatment of acute exacerbation of chronic obstructive pulmonary disease（COPD）.Methods：A total of 50 patients with acute exacerbation of obstructive pulmonary disease were treated with budesonide combined with salbutamol,and the clinical efficacy,averse reactions,pulmonary ventilation function and dyspnea score before and after treatment were evaluated.Results：The clinical treatment efficiency was 94.0% in this group of patients,and the incidence of adverse reactions was 12.0%.After treatment,their FVC,FEV1,FEV1/FVC,PEF,dyspnea scores were significantly better than before treatment,and the difference was statistically significant（P〈0.05）.Conclusion：The use of budesonide combined with salbutamol in patients with acute obstructive pulmonary disease during acute exacerbation can significantly improve the symptoms of pulmonary function and dyspnea.It has good clinical efficacy and safety.