胰腺癌定量双能CT碘图与CT灌注参数相关性研究

Correlation between quantitative dual-energy CT iodine maps and CT perfusion parameters in patients with pancreatic carcinoma

目的:探讨胰腺癌、正常胰腺组织时间特异性双能CT碘图参数与对应部分CT灌注参数间是否存在相关性?时间特异性单期双能CT扫描能否成为CT灌注临床应用的有效替代方法?方法:入组胰腺癌患者32例,男19例,女13例。记录正常胰腺组织实质期时间,利用两独立样本t检验比较胰腺癌与正常胰腺组织碘浓度(iodine concentration,IC),选用Pearson相关计算胰腺癌、正常胰腺组织IC与对应部分CT各灌注参数间的相关性。比较全胰腺CT灌注与时间特异性单期双能CT有效辐射剂量。结果:正常胰腺组织实质期时间为对比剂注入后的(31.75±3.50)s。胰腺癌与正常胰腺组织IC有统计学意义(P=0.000)。胰腺癌、正常胰腺组织碘图参数IC与CT灌注参数血流量(blood flow,BF)、血容量(blood volume,BV)间有中度相关(r分别0.644、0.523、0.547、0.511)。时间特异性单期双能CT与全胰腺CT灌注有效辐射剂量分别为(1.13±0.14)mSv vs 8.61mSv。结论:胰腺癌时间特异性单期双能CT碘图参数IC与CT灌注参数BF、BV间有中度相关。双能CT碘图在某些临床疾病的诊断与评估中有望成为CT灌注的有效替代检查方法。

Objective：To investigate whether a potential correlation exists between quantitative dual-energy CT iodine maps and CT perfusion parameters in patients with pancreatic cancer.Furthermore,can time-specific single-phase dual-energy CT be an effective surrogate for CT perfusion in clinical applications.Methods：Thirty-two patients（19 males and 13 females）with pancreatic cancer enrolled in this study.The peak time of normal pancreatic tissue enhancement was recorded.Independent sample t test was used to compare iodine concentration（IC）of pancreatic cancers and normal tissues.The pearson correlation coefficient was used to calculate correlation coefficients between IC and CT perfusion parameters of pancreatic cancers and normal tissues.The effective radiation dose of CT perfusion and single phase dual-energy CT were compared.Results：The parenchymal phase time of normal pancreatic tissue was（31.75±3.50）s after the initiation of contrast medium injection.The difference in IC between pancreatic cancers and normal tissues was statistical significant（P=0.000）.There was a moderate but measurable correlation between IC and CT perfusion parameters（BF,BV）in pancreatic cancer and normal pancreatic tissue（r=0.644,0.523;0.547,0.511 respectively）.The effective radiation dose of single phase dual-energy CT and whole pancreas CT perfusion was（1.13±0.14）mSv vs8.61 mSv.Conclusion：There is moderate correlation between time specific single phase dual-energy CT iodine maps parameters（IC）and CT perfusion parameters（BF,BV）in pancreatic cancer and normal pancreatic tissue.Time specific single phase dual-energy CT may be an effective surrogate for CT perfusion in diagnosis and evaluation of some clinical disease.Further study would be recommended to refine these results and to refine benefits for patients.