摘要
无论在先天性长QT综合征(LQTs),还是获得性长QT综合征,女性性别都是尖端扭转型室性心动过速(TdP)发展的独立危险因素。研究表明性激素可能影响心肌复极电流,从而影响心肌复极的性别差异。本文综述了性激素对心脏离子通道电流的影响,以及对药物诱发的长QT综合征性别差异的影响,并用计算机模拟的方法阐明性激素诱发心律失常的机制。
Female gender is an independent risk factor for the development of torsade de pointes （TdP） an＇hythmias not only in congenital long QT syndromes （LQTs）but also in acquired long QT syndromes. Clinical evidences imply that sex steroid hormones appear to play important roles in gender differences by affecting the cardiac repolarization process of action potential. This review- summarizes the effects of sex homlones on cardiac ion channel currents and the effects of gender differences on drug-induced long QT syndromes, and reveals the mechanism of sex hormone induced an＇hythmia by computer simulation
作者
王翠华
贾心乐
刘衍恭
郑明奇
WANG Cui-hua;JIA Xin-le;LIU Yan-gong;ZHENG Ming-qi(Department of Heart Center,the First Hospital of Hebei Medical Uaiversity,Shijiazhuang 050031,China;Department ofPathophysiology,Oita Uaiversity School of Medicine,Japart)
出处
《天津医药》
CAS
北大核心
2018年第6期665-669,共5页
Tianjin Medical Journal
基金
河北省科技计划项目(16277707D)
河北省自然科学基金面上项目(H2015206386)
河北省医学科学研究重点课题计划(20150191)
关键词
性腺甾类激素
心律失常
心性
性别因素
心肌复极
综述
gonadal steroid hormones
arrhythmias
cardiac
sex factors
myocardial repolarization
review
