奥曲肽联合艾司奥美拉唑治疗急性非静脉曲张性上消化道出血的疗效研究

Efficacy of Octreotide Combined with Esoprazole in the Treatment of Acute Non-varicose Upper Gastrointestinal Hemorrhage

目的:探讨奥曲肽联合艾司奥美拉唑治疗急性非静脉曲张性上消化道出血的疗效。方法:2017年8月~2018年3月,选取某院收治的80例急性非静脉曲张性上消化道出血患者,随机分成两组,各40例。对照组进行艾司奥美拉唑单独治疗,观察组进行艾司奥美拉唑联合奥曲肽治疗,比较两组患者的治疗效果。结果:经治疗,观察组的止血时间短于对照组,观察组的输血量明显少于对照组,观察组的再出血率明显低于对照组,观察组的治疗有效率明显优于对照组,对比均有统计学意义(P<0.05)。结论:急性非静脉曲张性上消化道出血患者应用奥曲肽联合艾司奥美拉唑药物治疗,可有效减少出血量和输血量,缩短止血时间,控制再出血率,效果显著,值得临床推广。

Objective：To probe into the clinical effects of octreotide combined with esomeprazole in treatment of acute non-varicose upper gastrointestinal hemorrhage.Methods：80 cases of patients with acute nonvaricose upper gastrointestinal bleeding treated in a hospital from August 2017 to March 2018 were selected and randomly divided into two groups,with 40 cases in each group.The control group were treated with esomeprazole alone,while the observation group were treated with omeprazole combined with octreotide.Then the treatment effects of two groups of patients were compared.Results：After the treatment,the hemostasis time in the observation group was shorter than that in the control group.The volume of blood transfusion in the observation group was significantly less than that in the control group.The rebleeding rate in the observation group was significantly lower than that in the control group.The effective rate in the observation group was significantly better than that in the control group,all of them were P〈0.05.Conclusion：The octreotide combined with esomeprazole in treatment of patients with acute non-varicose upper gastrointestinal hemorrhage can effectively reduce the amount of bleeding and transfusion volume,shorten the hemostasis time,and control the rate of rebleeding,which has significant clinical effect and is worthy of clinical promotion.