饲用碘酸钙/海藻酸钠微球的制备

Preparation of sodium alginate microspheres supported calcium iodate for feeds

为提高碘酸钙在饲料中的稳定性,以碘酸钙为芯材,海藻酸钠(Sodium alginate,SA)为壁材,纳米碳酸钙为交联剂,将碘酸钙分散于液体石蜡中,采用内源乳化法制备了碘酸钙/海藻酸钠凝胶微球.采用傅里叶红外光谱和扫描电子显微镜对碘酸钙/海藻酸钠凝胶微球进行了表征,并通过单因素法系统考察了碘酸钙/海藻酸钠凝胶微球制备工艺对其载药率和包封率的影响.结果表明,碘酸钙以晶体形式负载于碘酸钙/海藻酸钠凝胶微球上;在海藻酸钠质量浓度为12 g·L^(-1),纳米碳酸钙质量分数为SA的1/2,Span80质量分数为2%,酸钙物质的量比为6.9∶1,碘酸钙质量为1.2 g,油相搅拌速度500 r·min^(-1),油水体积比为3∶1,乳化30 min,富集90 min和交联25 min条件下工艺最优,其制备的碘酸钙/海藻酸钠凝胶微球载药率和包封率分别为41.0%和71.8%.

In order to improve the stability of calcium iodate in feeds,Calcium iodate have been distributed into liquid paraffin at first,then the microsphere of calcium iodate（Ca（IO3）2/SA microsphere）were prepared by emulsification/internal gelation with sodium alginate as wall material and Nano-calcium carbonate as cross linker.The Ca（IO3）2/SA microspheres were characterized by FT-IR and SEM,and the influence of preparation conditions of Ca（IO3）2/SA microsphere on the loading content of calcium iodate（LC）and encapsulation efficiency（EE）was studied systematically by the single-factor method.The results showed that the loaded calcium iodate was loaded in crystalline form in microspheres.The optimized condition of preparation of Ca（IO3）2/SA microsphere were as follows：sodium alginate concentration12 g·L^-1,Nano-calcium 1/2,Span80 2%,acid-calcium substance ratio 6.9∶1,calcium iodate mass1.2 g,oil phase stirring speed 500 r·min^-1,oil-water volume ratio 3∶1,emulsification time 30 min,enrichment time 90 min,crosslinking time 25 min.The loading content（LC）and encapsulation efficiency（EE）of Ca（IO3）2/SA microsphere in the optimized condition were 41.0%and 71.8%,respectively.