类泛素化修饰Neddylation在心脏生物学中的作用

The Role of Ubiquitin-like Modification of Neddylation in Cardiac Biology

Neural precursor cell-expressed developmentally downregulated 8(NEDD8)是类泛素蛋白家族的一员,其结构与泛素相似,通过E1激活酶、E2结合酶和E3连接酶等酶促级联反应对蛋白进行翻译后修饰,这一过程即为neddylation。Neddylation异常已被证实与癌症、神经退行性疾病和先天性心脏病等多种疾病密切相关。近年来,neddylation和deneddylation(底物上的NEDD8在deneddylation酶的作用下被去除,称为deneddylation)在心血管系统中的作用备受关注,本文将主要阐述neddylation的生物学过程及其在心脏生物学中的作用。

Neural precursor cell expressed developmentally downregulated 8（NEDDS） is a mere ber of ubiquitin like protein family and its structure is similar to that of ubiquitin. Neddylation is a post translational protein modification that conjugates an ubiquitin like protein NEDD8 to target proteins,which is mediated by a cascade of three NEDD8 specific enzymes,an E1 activating enzyme,an E2 realities have been generative diseases conjugating enzyme and one of the several E3 confirmed to be closely related to various diseases and congenital heart diseases. In recent years, the ases. Neddylation abnor such as cancer,neurode role of neddylation and deneddylation in the cardiovascular system has attracted much attention. This article will mainly describe the biological processes of neddylation and its role in cardiac biology.