二甲双胍在Ⅰ型糖尿病治疗中的应用进展

Application of Metformin in Treatment of Type Ⅰ Diabetes

Ⅰ型糖尿病(T1DM)又称胰岛素依赖型糖尿病,胰岛素替代治疗为其治疗基础,但胰岛素的长期使用会造成低血糖、体质量增加等诸多不良现象。Ⅰ型糖尿病的二甲双胍辅助治疗可有效减少胰岛素用量,预防心血管并发症,并已经得到临床研究证实。该研究对80例成人Ⅰ型糖尿病患者进行分组治疗,旨在其对减少胰岛素用量、心血管并发症预防的作用机制、有效性及安全性进行进一步的临床研究,结果显示治疗3个月后加用二甲双胍患者体质量指数及血糖水平均低于单独胰岛素治疗患者,且两组患者治疗期间均未发生低血糖事件。

Type Ⅰ diabetes mellitus（T1DM） is also called insulin-dependent diabetes mellitus. Insulin substitute therapy is the basis of its treatment. However, long-term use of insulin could cause many undesirable phenomena such as hypoglycemia and increased body mass. Metformin adjuvant therapy for T1DM can effectively reduce the dose of insulin and prevent cardiovascular complications, and it has been confirmed by clinical studies, but its mechanism of action, effectiveness and safety in reducing insulin dosage and preventing cardiovascular complications need further clinical research.